254967-36-7

Basic information

• Product Name: 3-AMino-1-(4-fluorophenyl)propan-1-ol
• Synonyms: 3-AMino-1-(4-fluorophenyl)propan-1-ol
• CAS NO: 254967-36-7
• Molecular Formula: C9H12FNO
• Molecular Weight: 169.1960832
• Mol File: 254967-36-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 296.8°C at 760 mmHg
• Flash Point: 133.3°C
• Appearance: /
• Density: 1.167g/cm³
• Vapor Pressure: 0.000631mmHg at 25°C
• Refractive Index: 1.54
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-AMino-1-(4-fluorophenyl)propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMino-1-(4-fluorophenyl)propan-1-ol(254967-36-7)
• EPA Substance Registry System: 3-AMino-1-(4-fluorophenyl)propan-1-ol(254967-36-7)

Safety Data

• Hazardous Substances Data: 254967-36-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H12FNO/c10-8-3-1-7(2-4-8)9(12)5-6-11/h1-4,9,12H,5-6,11H2

Upstream product

• 4640-67-9 3-(4-fluorophenyl)-3-oxopropionitrile 
• 63131-29-3 methyl 4-fluorobenzoyl acetate 
• 1589599-31-4 (3S)-3-(4-fluorophenyl)-3-hydroxypropanamide 
• 462-06-6 fluorobenzene 
• 57056-43-6 3-bromo-1-(4-fluorophenyl)propan-1-one 
• 1467720-20-2 3-bromo-1-(4-fluorophenyl)propan-1-ol 
• 1481452-70-3 3-azido-1-(4-fluorophenyl)propan-1-ol 

Relevant articles and documents

AMINOTRIAZOLOPYRIDINES AS KINASE INHIBITORS

Compounds having formula (I) (IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein: (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX).

A modular lead-oriented synthesis of diverse piperazine, 1,4-diazepane and 1,5-diazocane scaffolds

Piperazines are found widely in commercially-available compounds and bioactive molecules (including many drugs). However, in the vast majority of these molecules, the piperazine ring is isolated (i.e. not fused to another ring) and is not substituted on any of its carbon atoms. A modular synthetic approach is described in which combinations of cyclic sulfamidate and hydroxy sulfonamide building blocks may be converted into piperazines and related 1,4-diazepine and 1,5-diazocane scaffolds. By variation of the combinations of building blocks used, it was possible to vary the ring size, substitution and configuration of the resulting heterocyclic scaffolds. The approach was exemplified in the synthesis of a range of heterocyclic scaffolds that, on decoration, would target lead-like chemical space. It was demonstrated that lead-like small molecules based on these scaffolds would likely complement those found in large compound collections. This journal is the Partner Organisations 2014.

Polymer-supported chiral sulfonamide catalyzed one-pot reduction of β-keto nitriles: A practical synthesis of (R)-fluoxetine and (R)-duloxetine

Enantioselective reduction of β-keto nitriles to optically active 1,3-amino alcohols has been carried out in one step using an excess of borane-dimethyl sulfide complex as a reductant and a polymer-supported chiral sulfonamide as a catalyst with moderate to high enantioselectivity. The facile and enantioselective method to prepare optically active 1,3-amino alcohols to be converted into 3-aryloxy-3-arylpropylamine-type antidepressant drugs (R)-fluoxetine, and (R)-duloxetine is also reported.