25507-29-3 Usage
General Description
6-amino-5-(benzylamino)pyrimidine-2,4(1H,3H)-dione, also known as Aminopterin, is a chemical compound used as a medication and as an agricultural herbicide. It belongs to the class of folic acid analogs and works by inhibiting the enzyme dihydrofolate reductase, ultimately preventing the synthesis of DNA and RNA. Aminopterin has been used as a chemotherapy agent for the treatment of leukemia and other malignant tumors, although it is now rarely used due to its toxic side effects. It has also been used as a folate antagonist herbicide to control the growth of weeds, although its use in this context has largely been replaced by safer and more effective compounds. Overall, the compound is a potent inhibitor of folate metabolism with potential applications in medicine and agriculture.
Check Digit Verification of cas no
The CAS Registry Mumber 25507-29-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,5,0 and 7 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 25507-29:
(7*2)+(6*5)+(5*5)+(4*0)+(3*7)+(2*2)+(1*9)=103
103 % 10 = 3
So 25507-29-3 is a valid CAS Registry Number.
25507-29-3Relevant articles and documents
Fragment Discovery for the Design of Nitrogen Heterocycles as Mycobacterium tuberculosis Dihydrofolate Reductase Inhibitors
Shelke, Rupesh U.,Degani, Mariam S.,Raju, Archana,Ray, Mukti Kanta,Rajan, Mysore G. R.
, p. 602 - 613 (2016/08/28)
Fragment-based drug design was used to identify Mycobacterium tuberculosis (Mtb) dihydrofolate reductase (DHFR) inhibitors. Screening of ligands against the Mtb DHFR enzyme resulted in the identification of multiple fragment hits with IC50 values in the range of 38–90 μM versus Mtb DHFR and minimum inhibitory concentration (MIC) values in the range of 31.5–125 μg/mL. These fragment scaffolds would be useful for anti-tubercular drug design.
