25519-82-8

Basic information

• Product Name: Methanone,(4-methoxyphenyl)-4-piperidinyl-, hydrochloride (1:1)
• Synonyms: Ketone,p-methoxyphenyl 4-piperidyl, hydrochloride (8CI);Methanone,(4-methoxyphenyl)-4-piperidinyl-, hydrochloride (9CI);4-(4-Methoxybenzoyl)piperidine hydrochloride;4-(p-Methoxybenzoyl)piperidinehydrochloride
• CAS NO: 25519-82-8
• Molecular Formula: C₁₃H₁₇NO₂*ClH
• Molecular Weight: 255.7405
• Product Categories: Pyrans, Piperidines &Piperazines;Pyrans, Piperidines & Piperazines
• Mol File: 25519-82-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 260-264°C
• Boiling Point: 371.3 °C at 760 mmHg
• Flash Point: 178.3 °C
• Appearance: /
• Vapor Pressure: 1.04E-05mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methanone,(4-methoxyphenyl)-4-piperidinyl-, hydrochloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone,(4-methoxyphenyl)-4-piperidinyl-, hydrochloride (1:1)(25519-82-8)
• EPA Substance Registry System: Methanone,(4-methoxyphenyl)-4-piperidinyl-, hydrochloride (1:1)(25519-82-8)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• Hazardous Substances Data: 25519-82-8(Hazardous Substances Data)

Usage

General Description

The chemical "Methanone, (4-methoxyphenyl)-4-piperidinyl-, hydrochloride (1:1)" is a pharmaceutical compound that is commonly known as remifentanil hydrochloride. It is a potent opioid analgesic that is frequently used as an intravenous medication for the management of acute pain during surgical procedures. Remifentanil hydrochloride works by binding to opioid receptors in the central nervous system, resulting in the attenuation of pain signals. Its rapid onset and short duration of action make it a valuable option for achieving fast and precise pain control, especially in the operating room. However,

InChI:InChI=1/C13H17NO2.ClH/c1-16-12-4-2-10(3-5-12)13(15)11-6-8-14-9-7-11;/h2-5,11,14H,6-9H2,1H3;1H

Upstream product

• 25519-81-7 1-(4-(4-methoxybenzoyl)piperidin-1-yl)ethanone 
• 25503-90-6 1-acetyl-piperidine-4-carboxylic acid 
• 498-94-2 isonipecotic acid 
• 59084-16-1 1-acetylpiperidine-4-carbonyl chloride 

Downstream Products

• 1356633-46-9 6-(4-(4-methoxybenzoyl)piperidine-1-carbonyl)nicotinic acid 
• 1356629-00-9 N-(1-(4-cyanobenzyl)piperidin-4-yl)-6-(4-(4-methoxybenzoyl)piperidine-1-carbonyl)nicotinamide 
• 1356633-44-7 methyl 6-(4-(4-methoxybenzoyl)piperidine-1-carbonyl)nicotinate 
• 1417917-74-8 2-(3-(4-(4-methoxybenzoyl)piperidin-1-yl)-2-oxopyrrolidin-1-yl)acetonitrile 
• 1417917-80-6 ethyl 2-(3-(4-(4-methoxybenzoyl)piperidin-1-yl)-2-oxopyrrolidin-1-yl)acetate 
• 420786-53-4 4-(4-hydroxy)benzoylpiperidine 

Relevant articles and documents

Structural and Functional Study of the Klebsiella pneumoniae VapBC Toxin-Antitoxin System, including the Development of an Inhibitor That Activates VapC

Klebsiella pneumoniae is one of the most critical opportunistic pathogens. TA systems are promising drug targets because they are related to the survival of bacterial pathogens. However, structural information on TA systems in K. pneumoniae remains lacking; therefore, it is necessary to explore this information for the development of antibacterial agents. Here, we present the first crystal structure of the VapBC complex from K. pneumoniae at a resolution of 2.00 ?. We determined the toxin inhibitory mechanism of the VapB antitoxin through an Mg2+ switch, in which Mg2+ is displaced by R79 of VapB. This inhibitory mechanism of the active site is a novel finding and the first to be identified in a bacterial TA system. Furthermore, inhibitors, including peptides and small molecules, that activate the VapC toxin were discovered and investigated. These inhibitors can act as antimicrobial agents by disrupting the VapBC complex and activating VapC. Our comprehensive investigation of the K. pneumoniae VapBC system will help elucidate an unsolved conundrum in VapBC systems and develop potential antimicrobial agents.

Benzoylpiperidylalkylindoles

New benzoylpiperidylalkylindoles and related compounds possessing tranquilizing, anti-hypertensive and analgesic properties and a process for the preparation thereof are described.