2557-70-2 Usage
Description
2-(Trifluoroacetyl)pyrrole, an α,α,α-trifluoromethyl ketone, is a 2-substituted pyrrole derivative that has been synthesized by reacting pyrrole with trifluoroacetic anhydride in benzene at 0°C. 2-(Trifluoroacetyl)pyrrole has potential applications in various industries due to its unique chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
2-(Trifluoroacetyl)pyrrole is used as an intermediate for the synthesis of various pharmaceutical compounds. Its unique trifluoromethyl ketone group and 2-substituted pyrrole structure make it a valuable building block for the development of new drugs with improved properties, such as enhanced bioavailability, potency, and selectivity.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-(Trifluoroacetyl)pyrrole serves as a versatile starting material for the preparation of a wide range of organic compounds. Its reactivity can be exploited to form various functional groups and complex molecular structures, which can be applied in different areas, such as materials science, agrochemistry, and specialty chemicals.
Used in Enantioselective Catalysis:
The enantioselective hydrogenation of 2-(Trifluoroacetyl)pyrrole to form the corresponding alcohol has been investigated using a 5wt.% Pt/Al2O3 catalyst chirally modified by new synthetic chiral amines. This application highlights the potential of 2-(Trifluoroacetyl)pyrrole in the development of enantioselective catalysts and processes, which are crucial for the production of chiral compounds with high enantiomeric purity, particularly in the pharmaceutical and agrochemical industries.
Check Digit Verification of cas no
The CAS Registry Mumber 2557-70-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,5,5 and 7 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 2557-70:
(6*2)+(5*5)+(4*5)+(3*7)+(2*7)+(1*0)=92
92 % 10 = 2
So 2557-70-2 is a valid CAS Registry Number.
InChI:InChI=1S/C6H4F3NO/c7-6(8,9)5(11)4-2-1-3-10-4/h1-3,10H
2557-70-2Relevant articles and documents
A closer insight into the mechanism operating in the trifluoroacetylation of pyrrole. New trifluoromethyl pyrroylmethane discovered
Peláez,Burgos Paci,Argüello
, p. 1934 - 1938 (2009)
A former studied reaction of acetylation of pyrrole was revisited and this allowed the identification of new compounds and the isolation and characterization of a very stable solid (2,2′,2″-(2,2,2-trifluoroethane-1,1,1-triyl)tris(1H-pyrrole)). All these m
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Cooper
, p. 1382 (1958)
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Catalytic asymmetric hydrogenation of α-CF3- or β-CF3-Substituted acrylic acids using Rhodium(I) complexes with a combination of chiral and achiral ligands
Dong, Kaiwu,Li, Yang,Wang, Zheng,Ding, Kuiling
supporting information, p. 14191 - 14195 (2014/01/06)
Only the mixture works! Acrylic acid derivatives with CF3 substituents in α or β position were efficiently hydrogenated in the presence of a RhI complex with a chiral secondary phosphine oxide (SPO; see scheme) and an achiral Ph3P as ligands. The corresponding propanoic acid derivatives were obtained with generally high conversion (>99 %) and high enantioselectivity (92->99 %). Copyright