256224-02-9Relevant articles and documents
An improved process for the manufacture of 5′-O-(4,4′-dimethoxytrityl)-N2-isobutyryl-2′-O-(2-methoxyethyl)guanosine
McPherson, Andrew K.,Capaldi, Daniel,Chen, Lijian,Olsen, Philip
, p. 2583 - 2590 (2020/12/29)
A revised, optimized process for the manufacture of 5′-O-(4,4′-dimethoxytrityl)-N2-isobutyryl-2′-O-(2- methoxyethyl)guanosine (MOE G PNS) that controls critical impurities to less than 0.2% was developed. The 2′-O-alkylation of 2,6-diaminopurine riboside
Process research on the preparation of DMT protected 2′-O- methoxyethylguanosine for oligonucleotide synthesis in therapeutic applications
Taj, Shabbir Ali S.,Narayanan,Meenakshi, S. Suman,Sanghvi, Yogesh S.,Ross, Bruce S.,Ravikumar, Vasulinga T.
, p. 1024 - 1033 (2008/12/22)
An optimized process to synthesize DMT protected 2′-O- methoxyethylguanosine is described. A key step involves the enzymatic deamination of a mixture of alkylated products to selectively afford the desired material without resorting to chromatography for purification. This approach was scaled up to kilogram quantities for use in oligonucleotide therapeutics. Copyright Taylor & Francis Group, LLC.