2567-29-5 Usage
Description
4-BROMOMETHYLBIPHENYL, also known as 4-(bromomethyl)biphenyl, is a biphenyl derivative characterized by the presence of a bromine atom attached to the methyl group. This chemical structure endows it with unique properties that make it valuable in various applications, particularly in the pharmaceutical and chemical industries.
Uses
Used in Pharmaceutical Industry:
4-BROMOMETHYLBIPHENYL is used as a key intermediate compound for the synthesis of various pharmaceutical compounds. One of its primary applications is in the preparation of protein tyrosine phosphatase 1B inhibitors, which play a crucial role in the treatment of type 2 diabetes and obesity by modulating insulin signaling pathways.
Used in Chemical Industry:
4-BROMOMETHYLBIPHENYL is used as an atom transfer radical polymerization (ATRP) initiator. ATRP is a controlled radical polymerization technique that allows for the synthesis of polymers with well-defined molecular weights, narrow molecular weight distributions, and controlled architectures. As an initiator, 4-BROMOMETHYLBIPHENYL helps in the controlled growth of polymer chains, enabling the production of polymers with specific properties tailored for various applications, such as coatings, adhesives, and advanced materials.
Check Digit Verification of cas no
The CAS Registry Mumber 2567-29-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,5,6 and 7 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2567-29:
(6*2)+(5*5)+(4*6)+(3*7)+(2*2)+(1*9)=95
95 % 10 = 5
So 2567-29-5 is a valid CAS Registry Number.
InChI:InChI=1/C13H11Br/c14-10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9H,10H2
2567-29-5Relevant articles and documents
Palladium(II) complexes of Y,C,Y-chelated phosphines: Synthesis, structure, and catalytic activity in Suzuki-Miyaura reaction
Reznicek, Tomas,Dostal, Libor,Ruzicka, Ales,Kulhanek, Jiri,Bures, Filip,Jambor, Roman
experimental part, p. 173 - 179 (2012/04/23)
The phosphines L1PPh2 (1) and L2PPh 2 (2) containing different Y,C,Y-chelating ligands, L1 = 2,6-(tBuOCH2)2C6H3 - and L2 = 2,6-(Me2NCH2) 2C6H3-, were treated with PdCl 2 and di-Aμ-chloro-bis[2-[(N,N-dimethylamino)methyl]phenyl- C,N]-dipalladium(II) and yielded complexes trans-{[2,6-(tBuOCH 2)2C6H3]PPh2} 2PdCl2 (3), {[2,6-(Me2NCH2) 2C6H3]PPh2} PdCl2 (4), {[2,6-(tBuOCH2)2C6H 3]PPh2}Pd(Cl)[2-(Me2NCH2)C 6H4] (5) and {[2,6-(Me2NCH2) 2C6H3]PPh2}Pd(Cl)[2-(Me 2NCH2)C6H4] (6) as the result of different ability of starting phosphines 1 and 2 to complex PdCl2. Compounds 3-6 were characterized by 1H, 13C, 31P NMR spectroscopy and ESI-MS. The molecular structures of 3,4 and 6 were also determined by X-ray diffraction analysis. The catalytic activity of complexes 3-6 was evaluated in the Suzuki-Miyaura cross-coupling reaction.
