25711-25-5

Basic information

• Product Name: benzyl aziridine-1-carboxylate
• Synonyms: benzyl aziridine-1-carboxylate
• CAS NO: 25711-25-5
• Molecular Weight: 177.203
• Mol File: 25711-25-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: benzyl aziridine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl aziridine-1-carboxylate(25711-25-5)
• EPA Substance Registry System: benzyl aziridine-1-carboxylate(25711-25-5)

Safety Data

• Hazardous Substances Data: 25711-25-5(Hazardous Substances Data)

Upstream product

• 77987-49-6 benzyl 2-hydroxyethylcarbamate 
• 151-56-4 ethyleneimine 
• 501-53-1 benzyl chloroformate 
• 93407-96-6 2-(((benzyloxy)carbonyl)amino)ethyl 4-methylbenzenesulfonate 
• 671-51-2 N-ethoxycarbonylaziridine 
• 15205-57-9 tribenzyl phosphite 

Downstream Products

• 1180001-37-9 benzyl oct-3-ynylcarbamate 
• 1447346-44-2 C₁₃H₁₇NO₃ 
• 1215528-41-8 benzyl 3-methylmorpholine-4-carboxylate 
• 1028803-13-5 C₅₁H₆₉N₇O₁₀ 
• 1039756-05-2 ethyl 4-(((benzyloxy)carbonyl)amino)-2-cyano-2-phenylbutanoate 
• 908332-43-4 tert-butyl 2-(2-{[(benzyloxy)carbonyl]amino}ethyl)-5-biphenyl-4-yl-3-oxopentanoate 
• 147688-26-4 3,9-Dibenzyl-1,11-bis(benzyloxycarbonylamino)-6-oxa-3,9-diazaundecane-4,8-dione 
• 147688-15-1 13-Benzyloxycarbonylaminoethylen-1,4,7,10-tetraoxa-13-azacyclopentadecane 
• 147688-20-8 3-Benzyl-1,5-bis(benzyloxycarbonylamino)-3-azapentane 
• 147688-25-3 N-Benzyl-N'-benzyloxycarbonyl-ethylenediamine 
• 147688-19-5 7,16-Bis(benzyloxycarbonylaminoethylene)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane 
• 147688-22-0 3,12-Dibenzyl-1,14-bis(benzyloxycarbonylamino)-6,9-dioxa-3,12-diazatetradecane 
• 147688-17-3 16-Benzyloxycarbonylaminoethylene-1,4,7,10,13-pentaoxa-16-azacyclooctadecane 
• 1001404-36-9 H(8O₂,2)-CBZ 

Relevant articles and documents

CONJUGATED CHEMICAL INDUCERS OF DEGRADATION AND METHODS OF USE

The subject matter described herein is directed to antibody-CIDE conjugates (Ab-CIDEs), to pharmaceutical compositions containing them, and to their use in treating diseases and conditions where targeted protein degradation is beneficial.

Modular One-Step Three-Component Synthesis of Tetrahydroisoquinolines Using a Catellani Strategy

Reported is a modular one-step three-component synthesis of tetrahydroisoquinolines using a Catellani strategy. This process exploits aziridines as the alkylating reagents, through palladium/norbornene cooperative catalysis, to enable a Catellani/Heck/aza-Michael addition cascade. This mild, chemoselective, and scalable protocol has broad substrate scope (43 examples, up to 90 % yield). The most striking feature of this protocol is the excellent regioselectivity and diastereoselectivity observed for 2-alkyl- and 2-aryl-substituted aziridines to access 1,3-cis-substituted and 1,4-cis-substituted tetrahydroisoquinolines, respectively. Moreover, this is a versatile process with high step and atom economy.

LUMINESCENT MACROCYCLIC LANTHANIDE COMPLEXES

The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.