257619-71-9Relevant articles and documents
Diastereoselective alkylation of aromatic enamidone functionality in isoindole series: A convenient route to chiral aza-analogues of Senkyunolide- E
Eddine, Abderrahim Chihab,Da?ch, Adam,Jilale, Abderrahim,Decroix, Bernard
, p. 2907 - 2914 (2007/10/03)
Chiral aza-analogues (2a) and (2b) of Senkyunolide-E were efficiently synthesized in a four-step sequence (72 and 70 % overall yields respectively) from the commercially available phthalic anhydride and (S)-(-)-α- phenylethylamine. The key step consisted in the 1,2-addition of Grignard reagents onto enamidone type compounds (8) and (9). These latters were regioselectively obtained from the parent ω-alkynyl-ω-carbinol lactams (6) and (7) by a Meyer-Schuster rearrangement.