2578-57-6

Basic information

• Product Name: H-PRO-GLY-OH
• Synonyms: prolylglycine;PRO-GLY MONOHYDRATE;PRO-GLY;L-PRO-GLN;L-PROLYLGLYCINE;H-PRO-GLY-OH;Glycine, L-prolyl- (9CI);2-(prolylamino)acetic acid
• CAS NO: 2578-57-6
• Molecular Formula: C₇H₁₂N₂O₃
• Molecular Weight: 172.18
• Product Categories: PYRROLE;Dipeptides;Dipeptides and Tripeptides;Peptides
• Mol File: 2578-57-6.mol
• Article Data: 12

Chemical Properties

• Melting Point: 236℃
• Boiling Point: 468.5 °C at 760 mmHg
• Flash Point: 237.1 °C
• Appearance: White to off white powder
• Density: 1.266 g/cm³
• Vapor Pressure: 4.5E-10mmHg at 25°C
• Refractive Index: 1.511
• Storage Temp.: −20°C
• CAS DataBase Reference: H-PRO-GLY-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-PRO-GLY-OH(2578-57-6)
• EPA Substance Registry System: H-PRO-GLY-OH(2578-57-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 2578-57-6(Hazardous Substances Data)

Usage

Description

H-PRO-GLY-OH, also known as a dipeptide consisting of glycine with an L-prolyl group attached to its alpha-amino nitrogen, is a white powder substance. It is formed through the enzymatic action of prolinase (prolyl dipeptidase) and possesses unique chemical properties that make it suitable for various applications across different industries.

Uses

Used in Pharmaceutical Industry:
H-PRO-GLY-OH is used as a substrate for prolinase (prolyl dipeptidase) due to its dipeptide structure, which is essential for the study and development of drugs targeting this enzyme. This application is crucial in understanding the enzyme's role in various biological processes and its potential as a therapeutic target.
Used in Research and Development:
H-PRO-GLY-OH serves as a valuable compound in the field of research and development, particularly in the study of enzyme kinetics, protein-ligand interactions, and the development of novel inhibitors or activators for prolinase. Its unique structure allows researchers to explore its potential in modulating enzyme activity and understanding the underlying mechanisms.
Used in Chemical Synthesis:
As a dipeptide, H-PRO-GLY-OH can be utilized as a building block in the synthesis of more complex peptides and proteins. This application is particularly relevant in the fields of biotechnology and materials science, where the development of novel bioactive molecules and materials with specific properties is of great interest.
Used in Cosmetics Industry:
Due to its dipeptide nature and potential effects on skin health, H-PRO-GLY-OH may find applications in the cosmetics industry as an ingredient in anti-aging or skin repair products. Its ability to modulate enzyme activity could potentially contribute to improved skin health and appearance.

Purification Methods

Recrystallise L-prolylglycine from water at 50-60o by addition of EtOH. [Appel et al. Chem Ber 108 2680 1975, Rydon & Smith J Chem Soc 3642 1956.]

InChI:InChI=1/C7H12N2O3/c10-6(11)4-9-7(12)5-2-1-3-8-5/h5,8H,1-4H2,(H,9,12)(H,10,11)/t5-/m0/s1

Upstream product

• 3705-27-9 (S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione 
• 2766-18-9 N-carbobenzoxyprolylglycine 
• 490-01-7 N-(1-trifluoroacetyl-L-prolyl)-glycine ethyl ester 
• 51785-82-1 N-tert-butyloxycarbonyl-L-prolylglycine 
• 7536-45-0 Z-L-Pro-Gly-OBzl 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 2766-31-6 ethyl (N-benzoxycarbonyl-L-prolyl)glycinate 
• 34290-72-7 tert-butyloxycarbonyl-prolyl-glycine methyl ester 
• 33256-35-8 H-Pro-Gly-OMe 
• 61350-60-5 (S)-benzyloxycarbonyl-proline acid chloride 
• 147-85-3 L-proline 
• 2966-05-4 (S,S)-N-trifluoroacetylproline anhydride 
• 2133-40-6 L-proline methyl ester monohydrochloride 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 

Downstream Products

• 2441-81-8 N-[1-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-glycine 
• 117088-03-6 Z-Glyt-Pro-Gly 
• 19179-12-5 Hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione 
• 2766-18-9 N-carbobenzoxyprolylglycine 
• 68427-04-3 (S)-2-[({4-[Bis-(2-chloro-ethyl)-amino]-phenylcarbamoyl}-methyl)-carbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester 
• 849427-27-6 (S)-1-(2-{(S)-4-Methyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-pentanoylamino}-acetyl)-pyrrolidine-2-carboxylic acid ({4-[bis-(2-chloro-ethyl)-amino]-phenylcarbamoyl}-methyl)-amide 
• 68427-15-6 (S)-2-[(S)-1-(2-{(S)-2-[({4-[Bis-(2-chloro-ethyl)-amino]-phenylcarbamoyl}-methyl)-carbamoyl]-pyrrolidin-1-yl}-2-oxo-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester 
• 849427-29-8 C₃₄H₅₂Cl₂N₈O₆ 
• 849427-28-7 (4-{(S)-2-[(S)-1-(2-{(S)-2-[({4-[Bis-(2-chloro-ethyl)-amino]-phenylcarbamoyl}-methyl)-carbamoyl]-pyrrolidin-1-yl}-2-oxo-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-pyrrolidin-1-yl}-4-oxo-butyl)-carbamic acid benzyl ester 
• 276245-73-9 (S)-1-(Toluene-4-sulfonylaminocarbonyl)-pyrrolidine-2-carboxylic acid [(4-{[1-amino-1-methoxy-meth-(Z)-ylidene]-sulfamoyl}-phenylcarbamoyl)-methyl]-amide 
• 72122-62-4 L-tyrosyl-L-prolyl-L-phenylalanyl-L-prolyl-glycyl-L-prolyl-L-isoleucine 
• 85713-96-8 N-tert-butyloxycarbonyl-L-prolyl-L-phenylalanyl-L-prolylglycine 
• 47283-59-0 L-phenylalanyl-L-prolylglycine 
• 82289-41-6 des-Tyr¹-β-casomorphin-5 

Relevant articles and documents

Leonurine derivative and application thereof in preparing medicine for preventing or treating ischemic cerebrovascular diseases

The invention provides a leonurine derivative and application of the leonurine derivative in preparation of a medicine for preventing or treating ischemic cerebrovascular diseases. The leonurine derivative has a structure as shown in a general formula (I), wherein X is selected from O or NH; Y is selected from any one of natural amino acid, substituted amino acid or amino alcohol; Z is selected from H, proline and any substituted proline. Pharmacological experiments prove that the leonurine derivative provided by the invention has the effects of neuroprotection, cerebral infarction area reduction and animal neurobehavioral scoring, and is good in safety, so that the leonurine derivative has important significance for developing novel medicines for preventing or treating ischemic cerebrovascular diseases.

Aggregation propensity of amyloidogenic and elastomeric dipeptides constituents

This study demonstrates the self-assembly of N- and C-terminal protected dipeptides Phe–Gly and Pro–Gly which were derived from amyloidogenic and elastomeric peptide sequences. These constituents afforded nanostructured supramolecular ensembles through va

PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS

The invention relates to a process for straightening keratin fibres, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibres, (ii) a step in which the temperature of the keratin fibres is raised, using a heating means, to a temperature of between 110 and 250° C.