260260-97-7

Basic information

• Product Name: (+)-(1R,2R)-2-azidocyclohexyl acetate
• Synonyms: (+)-(1R,2R)-2-azidocyclohexyl acetate
• CAS NO: 260260-97-7
• Molecular Weight: 183.21
• Mol File: 260260-97-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (+)-(1R,2R)-2-azidocyclohexyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(1R,2R)-2-azidocyclohexyl acetate(260260-97-7)
• EPA Substance Registry System: (+)-(1R,2R)-2-azidocyclohexyl acetate(260260-97-7)

Safety Data

• Hazardous Substances Data: 260260-97-7(Hazardous Substances Data)

Upstream product

• 108-05-4 vinyl acetate 
• 286-20-4 cyclohexane-1,2-epoxide 

Downstream Products

• 931-15-7 (1R,2R)-2-aminocyclohexanol 
• 110716-78-4 (1R,2R)-trans-2-azidocyclohexanol 

Relevant articles and documents

Stereoselective synthesis of 1,2,3-triazolooxazine and fused 1,2,3-triazolo-d-lactone derivatives

The stereoselective synthesis of 1,2,3-triazolooxazine and fused 1,2,3-triazolo-d-lactone by applying chemoenzymatic methods is described. trans-2-Azidocyclohexanol was successfully resolved by Novozyme 435 with an ee value of 99%. Installation of the alkyne moiety on the enantiomerically enriched azidoalcohol by O-alkylation, followed by intramolecular azide-alkyne [3+2] cycloaddition resulted in the desired 1,2,3-triazolooxazine derivative. Enantiomerically pure azidocyclohexanol was also subjected to the Huisgen 1,3-dipolar cycloaddition reaction with dimethylacetylene dicarboxylate, followed by intramolecular cyclization of the corresponding cycloadduct, to furnish a fused 1,2,3-triazolod-λ-lactone.