26084-46-8

Basic information

• Product Name: Benzenecarbothioic acid, O-cyclohexyl ester
• CAS NO: 26084-46-8
• Molecular Formula: C13H16OS
• Molecular Weight: 220.335
• Mol File: 26084-46-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzenecarbothioic acid, O-cyclohexyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenecarbothioic acid, O-cyclohexyl ester(26084-46-8)
• EPA Substance Registry System: Benzenecarbothioic acid, O-cyclohexyl ester(26084-46-8)

Safety Data

• Hazardous Substances Data: 26084-46-8(Hazardous Substances Data)

Upstream product

• 5873-86-9 methyl thiobenzoate 
• 22096-22-6 sodium cyclohexanolate 
• 108-93-0 cyclohexanol 
• 93-58-3 benzoic acid methyl ester 
• 108-85-0 1-bromocyclohexane 
• 557-91-5 1,1-Dibromoethane 
• 5614-37-9 cyclopentyl methyl ether 
• 1005-56-7 phenylcarbonochloridothioate 
• 220641-69-0 N-(2-amino-5-nitrophenyl)benzamide 
• 220642-01-3 N-thiobenzoyl-2-amino-5-nitroaniline 
• 65-85-0 benzoic acid 
• 108732-34-9 benzoic acid isobutoxycarbonyl ester 
• 220642-23-9 1-thiobenzoyl-6-nitrobenzotriazole 

Relevant articles and documents

Base-Catalyzed Transesterification of Thionoesters

Here we report a convenient synthesis of thionoesters by base-catalyzed transesterification. Benzyl and alkyl thionobenzoates and thionoheterobenzoates were efficiently prepared using various alcohols catalyzed by the corresponding sodium alkoxide. This methodology features a broad substrate scope, good to excellent yields, short reaction times, while simultaneously driving the reaction toward completion through the removal of the methanol byproduct. We also report the conversion of a small collection of thionobenzoates into the corresponding α,α-difluorobenzyl ethers to demonstrate the conversion of alcohols into difluorobenzyl or difluoroheterobenzyl ethers, a process that could prove useful for lead optimization in medicinal chemistry.

A general and efficient route to thionoesters via thionoacyl nitrobenzotriazoles

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