26116-56-3Relevant articles and documents
Synthetic method of isotope-labeled erythromycylamine
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Paragraph 0020; 0025; 0028; 0033; 0036; 0041; 0044, (2020/07/28)
The invention discloses a synthetic method of isotope-labeled erythromycylamine, belongs to the field of drug metabolism, and provides a synthetic method which is reasonable in process design, strongin operability and high in yield, can efficiently convert isotope-labeled raw materials into labeled target products, and can realize industrial production of isotope-labeled erythromycylamine. The method takes 13CD3 labeled methyl iodide as a starting raw material, the isotope-labeled erythromycylamine is synthesized by six steps of reactions, optimal preparation steps and reaction conditions arescreened out through a large number of experiments, the whole process is reasonable in design and high in operability, the labeled raw materials can be efficiently converted into labeled target products, the chemical purity of the labeled erythromycylamine prepared through the method can reach 98.5% or above, and the labeled isotope abundance is larger than 98.5%.
9-N-ethenyl derivatives of 9(S)-erythromycylamine
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, (2008/06/13)
The invention relates to 9-N-ethenyl derivatives of 9 (S)-erythromycylamine, new semisynthetic antibiotics of the macrolide class of the general formula (I) STR1 wherein R1 and R2 are the same or different and represent nitryl, a carboxyl group of the formula COOR3, wherein R3 represents a C1 -C4 alkyl group, or a keto group of the formula COR4, wherein R4 represents a C1 -C4 alkyl group, to their pharmaceutically acceptable addition salts with inorganic or organic acids, to a process for their preparation, to a process for the preparation of the pharmaceutical compositions as well as to the use of the obtained pharmaceutical compositions in the treatment of bacterial infections.
A MILD SINGLE-STEP REDUCTION OF OXIMES TO AMINES
Leeds, James P.,Kirst, Herbert A.
, p. 777 - 782 (2007/10/02)
A mild and convenient procedure has been developed for the reduction of oximes to amines in a single step involving treatment the oxime with TiCl3 in the presence of NaBH3CN.This method is especially useful for those substrates in which the intermeiate im