261635-77-2 Usage
Description
6-Chloro-4-(trifluoromethyl)nicotinic acid is an organic compound characterized by the presence of a chlorine atom at the 6th position and a trifluoromethyl group at the 4th position on the nicotinic acid backbone. It is a versatile building block in the field of organic synthesis, known for its potential applications in the development of various pharmaceutical compounds.
Uses
Used in Pharmaceutical Industry:
6-Chloro-4-(trifluoromethyl)nicotinic acid is used as a building block for the synthesis of N-aryl heteroarylcarboxamides, which are known to inhibit the protein-protein binding of WDR5. This inhibition plays a crucial role in the regulation of various cellular processes, making it a potential target for the development of new therapeutic agents.
Organic Synthesis:
In the field of organic synthesis, 6-chloro-4-(trifluoromethyl)nicotinic acid serves as a valuable intermediate for the preparation of a wide range of compounds with diverse biological activities. Its unique structural features allow for further functionalization and modification, enabling the synthesis of novel molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Research and Development:
6-Chloro-4-(trifluoromethyl)nicotinic acid is also utilized in research and development efforts, where it can be employed to explore new chemical reactions, reaction mechanisms, and synthetic strategies. This contributes to the advancement of knowledge in the field of organic chemistry and may lead to the discovery of new compounds with improved properties and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 261635-77-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,1,6,3 and 5 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 261635-77:
(8*2)+(7*6)+(6*1)+(5*6)+(4*3)+(3*5)+(2*7)+(1*7)=142
142 % 10 = 2
So 261635-77-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H3ClF3NO2/c8-5-1-4(7(9,10)11)3(2-12-5)6(13)14/h1-2H,(H,13,14)
261635-77-2Relevant articles and documents
INHIBITORS OF WDR5 PROTEIN-PROTEIN BINDING
-
, (2019/04/10)
The present application is directed to compounds of Formula I: (I) compositions comprising these compounds and their uses, for example as medicaments for the treatment of diseases, disorders or conditions mediated or treatable by inhibition of binding between WDR5 protein and its binding partners.
Logistic flexibility in the preparation of isomeric halopyridinecarboxylic acids
Cottet, Fabrice,Schlosser, Manfred
, p. 11869 - 11874 (2007/10/03)
Although there are many conceivable ways to funtionalize, and specifically carboxylate, 2-chloro-4-(trifluoromethyl)pyridine optionally at all three vacant positions, it is more straightforward to prepare only the 2-chloro-4- (trifluoromethyl)pyridine-3-carboxylic acid (1) from this precursor and the other 6-chloro-4-(trifluoromethyl)pyridine-2- and -3-carboxylic acids (2 and 3) from a different one, viz. 5-bromo-2-chloro-4-(trifluoromethyl)pyridine. In the same manner, it proved more convenient to convert 5-chloro-2-(trifluoromethyl) pyridine in only two of the corresponding acids (6 and 7) and to make the third one (8) from 3-bromo-5-chloro-2-(trifluoromethyl)pyridine as an alternative starting material. All model substrates for functionalization were readily accessible from the correspondingly substituted chloroiodopyridine through heavy halogen displacement by in situ generated (trifluoromethyl)copper. Graphical Abstract
