262606-35-9

Basic information

• Product Name: 2-Propen-1-one, 1-(2-aminophenyl)-3-(4-fluorophenyl)-
• CAS NO: 262606-35-9
• Molecular Formula: C15H12FNO
• Molecular Weight: 241.265
• Mol File: 262606-35-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 1-(2-aminophenyl)-3-(4-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1-(2-aminophenyl)-3-(4-fluorophenyl)-(262606-35-9)
• EPA Substance Registry System: 2-Propen-1-one, 1-(2-aminophenyl)-3-(4-fluorophenyl)-(262606-35-9)

Safety Data

• Hazardous Substances Data: 262606-35-9(Hazardous Substances Data)

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 551-93-9 2-aminoacetophenone 

Downstream Products

• 155370-03-9 2-(4-fluorophenyl)-1,2,3,4-tetrahydro-4-quinolone 
• 1334483-42-9 (2-(4-fluorophenyl)cyclopropyl)-1-(2-(tosylamino)phenyl)methanol 
• 1334483-50-9 (E)-2-(4-fluorostyryl)-1-tosylindoline 
• 1356037-61-0 C₂₃H₂₀FNO₃S 

Relevant articles and documents

Effect of substituents in the A and B rings of chalcones on antiparasite activity

Chalcones are a group of natural products with many recognized biological activities, including antiparasitic activity. Although a lot of chalcones have been synthetized and assayed against parasites, the number of structural features known to be involved in this biological property is small. Thus, in the present study, 21 chalcones were synthesized to determine the effect of substituents in the A and B rings on the activity against Leishmania braziliensis, Trypanosoma cruzi, and Plasmodium falciparum. The compounds were active against L. braziliensis in a structure-dependent manner. Only one compound was very active against T. cruzi, but none of them had a significant antiplasmodial activity. The electron-donating substituents in ring B and the hydrogen bonds at C-2′ with carbonyl affect the antiparasitic activity.

Chiral Phosphoric Acid Catalyzed Asymmetric Synthesis of 2-Substituted 2,3-Dihydro-4-quinolones by a Protecting-Group-Free Approach

Chiral 2-substituted 2,3-dihydro-4-quinolones were synthesized based on the chiral phosphoric acid catalyzed intramolecular aza-Michael addition reaction using N-unprotected 2-aminophenyl vinyl ketones as substrates in good yields with high enantioselectivities. (Chemical Equation Presented).