263247-61-6

Basic information

• Product Name: (R)-N-(4-pentenyl)-N-pentyl γ-benzyl-N_α-t-butoxycarbonylglutamic acid amide
• Synonyms: (R)-N-(4-pentenyl)-N-pentyl γ-benzyl-N_α-t-butoxycarbonylglutamic acid amide
• CAS NO: 263247-61-6
• Molecular Weight: 474.641
• Mol File: 263247-61-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-N-(4-pentenyl)-N-pentyl γ-benzyl-N_α-t-butoxycarbonylglutamic acid amide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-(4-pentenyl)-N-pentyl γ-benzyl-N_α-t-butoxycarbonylglutamic acid amide(263247-61-6)
• EPA Substance Registry System: (R)-N-(4-pentenyl)-N-pentyl γ-benzyl-N_α-t-butoxycarbonylglutamic acid amide(263247-61-6)

Safety Data

• Hazardous Substances Data: 263247-61-6(Hazardous Substances Data)

Upstream product

• 100-51-6 benzyl alcohol 
• 2578-33-8 D-glutamic acid-5-benzyl ester 
• 2100-17-6 4-pentenal 
• 6893-26-1 D-Glutamic acid 
• 821-09-0 n-Pent-4-enyl alcohol 
• 35793-73-8 N-(tert-butyloxycarbonyl)-γ-benzyl-D-glutamic acid 
• 263247-59-2 N-(4-pentenyl)-N-pentylamine 

Relevant articles and documents

Synthesis of a radoilabeled type A cholecystokinin receptor antagonist, (R)-N-pentyl-N-(4,5-di[3H]pentyl)N(α)-(3-quinolinoyl)glutamic acid amide

A method for the preparation of a radiolabeled CCK(A)-specific antagonist, (R)-N-pentyl-N-(4,5-di[3H]pentyl)N(α)-(3-quinolinoyl)glutamic acid amide, [3H]-A-65186, is described. (R)-γ-Benzyl-N-BOC-glutamic acid was coupled with N-(4-pentenyl)-N-pentylamine using BOPCl and TEA in dichloromethane to provide the corresponding amide. Deprotection of the α-amino moiety followed by coupling with 3-quinolinecarboxylic acid in the presence of EDCI, TEA, and HOBt in dichloromethane resulted in (R)-N-(4-pentenyl)-N-pentyl γ-benzyl-N(α)-(3-quinolinoyl)glutamic acid amide. Tritiation with concomitant hydrogenolysis of the benzyl ester proceeds smoothly to provide [3H]-A-65186.