263570-28-1 Usage
General Description
1-Isoquinolineacetic acid, 1,2,3,4-tetrahydro-6,7-dimethoxy-, methyl ester, also known as tetrahydroberberine, is an organic chemical compound with potential pharmacological applications. It is a derivative of berberine, a natural alkaloid found in several plants, and has been studied for its potential as an anti-inflammatory and anti-cancer agent. Tetrahydroberberine has also shown promise as a treatment for metabolic and cardiovascular disorders, as well as potential neuroprotective effects. The methyl ester form of the compound is often used to enhance its stability and bioavailability in pharmaceutical formulations. Further research is needed to fully understand the therapeutic potential and safety profile of 1-Isoquinolineacetic acid, 1,2,3,4-tetrahydro-6,7-dimethoxy-, methyl ester.
Check Digit Verification of cas no
The CAS Registry Mumber 263570-28-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,3,5,7 and 0 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 263570-28:
(8*2)+(7*6)+(6*3)+(5*5)+(4*7)+(3*0)+(2*2)+(1*8)=141
141 % 10 = 1
So 263570-28-1 is a valid CAS Registry Number.
263570-28-1Relevant articles and documents
A study of Aryl radical cyclization in enaminone esters
Navarro-Vazquez, Armando,Garcia, Alberto,Dominguez, Domingo
, p. 3213 - 3220 (2002)
Aryl radical cyclization in N-phenyl, N-benzyl, and N-phenethyl enaminone esters 1a-f was studied. N-Benzyl and N-phenethyl enaminones afforded 5-exo and 6-exo cyclization products, respectively, but radical cyclization did not occur in N-phenyl enaminones. The rate constants for the 5-exo and 6-exo cyclization processes in secondary enaminones were estimated as being on the order of 107 s-1 at 353 K; since DNMR experiments showed the rate constant for rotation around the enaminone C3-N bond to be on the order of 104 s-1 at this temperature, the initial enaminone configuration is maintained throughout the cyclization process. PM3 calculations suggested that the nonoccurrence of endo and 4-exo cyclizations is due to the corresponding transition structures involving significant distortion of the conjugated enaminone system.
