2639-17-0

Basic information

• Product Name: 2,5-bis(3-chlorophenyl)-1,3,4-oxadiazole
• CAS NO: 2639-17-0
• Molecular Formula: C₁₄H₈Cl₂N₂O
• Molecular Weight: 291.1321
• Mol File: 2639-17-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 448.2°C at 760 mmHg
• Flash Point: 224.9°C
• Density: 1.365g/cm³
• Vapor Pressure: 8.38E-08mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: 2,5-bis(3-chlorophenyl)-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-bis(3-chlorophenyl)-1,3,4-oxadiazole(2639-17-0)
• EPA Substance Registry System: 2,5-bis(3-chlorophenyl)-1,3,4-oxadiazole(2639-17-0)

Safety Data

• Hazardous Substances Data: 2639-17-0(Hazardous Substances Data)

Usage

Physical appearance

white to light brown crystalline powder

Solubility

insoluble in water, soluble in organic solvents

Uses

Synthesis of organic electronic materials
Intermediate in the production of pharmaceuticals and fine chemicals
Potential fluorescent material
Potential pesticide
Potential anti-cancer agent

Biological activities

Ability to inhibit cell proliferation
Ability to induce apoptosis in cancer cells
Further research needed to fully understand biological activities and potential applications

Upstream product

• 38192-14-2 3-chloro-N'-(3′-chlorobenzoyl)benzohydrazide 
• 618-46-2 m-Chlorobenzoyl chloride 
• 535-80-8 3-chlorobenzoate 
• 587-04-2 m-Chlorobenzaldehyde 
• 1673-47-8 3-chlorobenzhydrazide 
• 304456-31-3 C₁₄H₁₀Cl₂N₂O 

Downstream Products

• 787-84-8 N'-benzoylbenzohydrazide 
• 75029-44-6 1,3-dimethyl-5-benzoylpyrimidine-2,4(1H,3H)-dione 
• 75029-39-9 5-(3-Chlorbenzoyl)-1,3-dimethyluracil-(3-chlorbenzoyl)hydrazon 
• 65-85-0 benzoic acid 

Relevant articles and documents

Electrochemical oxidation of aldehyde-N-arylhydrazones into symmetrical-2,5-disubstituted-1,3,4-oxadiazoles

A convenient, efficient and one-pot synthesis of chemically and pharmaceutically interesting symmetrical-2,5-disubstituted-1,3,4-oxadiazoles is reported. The protocol involves anodic oxidation of aldehyde-N-arylhydrazones in anhyd. MeCN-LiClO4. Constant potential electrolysis carried out in an undivided cell and platinum electrodes leads to the formation of the corresponding oxadiazoles under ambient condition and the mechanism was deduced from voltammetry studies. The reaction proceeded smoothly with high atom economy. Springer Science+Business Media Dordrecht 2013.

An efficient one pot synthesis of 1,3,4-oxadiazoles

Various 1,3,4-oxadiazoles have been synthesized in excellent yields by BF3·Et2O promoted cyclodehydration of 1,2-diacyl and diaroyl hydrazines prepared in situ from corresponding acid chlorides and hydrazine.