2642-43-5

Basic information

• Product Name: thymidine 3'-monophosphate ammonium salt hydrate
• Synonyms: thymidine 3'-monophosphate ammonium salt hydrate;3'-thymidylic acid;Thymidine 3μ-monophosphate hydrate ammonium salt;3'-TMP;Thymidine 3'-phosphate;Thymidine 3'-phosphoric acid;Thymidine-3'-phosphoric acid;thymidine 3'-monophosphate
• CAS NO: 2642-43-5
• Molecular Formula: C₁₀H₁₅N₂O₈P
• Molecular Weight: 322.21
• Product Categories: Biochemicals and Reagents;Nucleosides, Nucleotides, Oligonucleotides;Nucleotides
• Mol File: 2642-43-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.654g/cm³
• Storage Temp.: −20°C
• PKA: 1.83±0.10(Predicted)
• CAS DataBase Reference: thymidine 3'-monophosphate ammonium salt hydrate(CAS DataBase Reference)
• NIST Chemistry Reference: thymidine 3'-monophosphate ammonium salt hydrate(2642-43-5)
• EPA Substance Registry System: thymidine 3'-monophosphate ammonium salt hydrate(2642-43-5)

Safety Data

• Hazardous Substances Data: 2642-43-5(Hazardous Substances Data)

Usage

Description

Thymidine 3'-monophosphate ammonium salt hydrate is a pyrimidine 2'-deoxyribonucleoside 3'-monophosphate that features thymine as its nucleobase. It is an essential component of DNA and plays a crucial role in various biological processes.

Uses

Used in Pharmaceutical Industry:
Thymidine 3'-monophosphate ammonium salt hydrate is used as an active pharmaceutical ingredient for the synthesis of antiviral and anticancer drugs. Its ability to integrate into DNA and RNA structures makes it a valuable compound in the development of therapeutic agents targeting viral and cancerous cells.
Used in Research and Development:
In the field of molecular biology and genetics, thymidine 3'-monophosphate ammonium salt hydrate serves as a vital research tool. It is utilized in various laboratory techniques, such as DNA sequencing, polymerase chain reaction (PCR), and site-directed mutagenesis, to study genetic information and manipulate DNA sequences.
Used in Diagnostic Applications:
Thymidine 3'-monophosphate ammonium salt hydrate is employed as a diagnostic agent in the detection and monitoring of certain diseases, particularly those involving DNA or RNA abnormalities. Its incorporation into diagnostic assays and tests aids in the accurate identification and assessment of various medical conditions.
Used in Biochemical Reagents:
As a biochemical reagent, thymidine 3'-monophosphate ammonium salt hydrate is used in the preparation of other nucleotide derivatives and the study of enzyme activities related to nucleic acid metabolism. Its presence in biochemical reactions helps researchers understand the mechanisms of DNA replication, repair, and regulation.

Upstream product

• 538-37-4 dibenzyl phosphochloridate 
• 50-89-5 thymidine 
• 56883-49-9 Thiophosphoric acid O-[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester 
• 68030-67-1 deoxythymidylyl-(3'->N)-phenylalanine 
• 68030-66-0 deoxythymidylyl-(5'->3')-deoxythymidine-(Pⁱⁿ->N)-phenylalanine 

Downstream Products

• 50-89-5 thymidine 
• 2476-56-4 5'-d(TpTp)-3' 

Relevant articles and documents

A NEW SOLID PHASE APPROACH FOR RAPID SYNTHESES OF OLIGONUCLEOTIDES BEARING A 3'-TERMINAL PHOSPHATE GROUP

Synthesis of pentanucleotide ApTpCpTpTp containing a 3'-terminal phosphomonoester group was accomplished with the help of the new phosphate-solid phase link 2-(4-carboxyphenylmercapto)ethanol; a similar molecule, 2-benzylsulfonylethanol, revealed interesting features as a temporary 3'-phosphate protecting group.

Synthesis and Properties of Thymidine Derivatives Bearing the (PhS)2P(O) and (PhS)(PhNH)P(O) groups

A new phosphorylating agent, cyclohexylammonium S-phenyl phosphoranilidothioate (2), was prepared in high yield.In this paper, the highly selective deprotection of the phenylthio or anilino group from thymidine 3',5'-diphosphate derivatives masked with th