26458-78-6 Usage
Description
4-Cyanoquinuclidine is an organic compound that serves as a key intermediate in the synthesis of various pharmaceuticals and chemical compounds. It is characterized by its unique structure, which includes a quaternary carbon atom and a nitrile group, making it a versatile building block for the development of new drugs and materials.
Uses
Used in Pharmaceutical Industry:
4-Cyanoquinuclidine is used as an intermediate in the synthesis of pleuromutilin derivatives, which are potent antimicrobial agents. These derivatives exhibit broad-spectrum activity against a wide range of bacteria, including both Gram-positive and Gram-negative organisms, making them valuable in the development of new antibiotics to combat drug-resistant infections.
Additionally, 4-Cyanoquinuclidine may be utilized in the development of other pharmaceutical compounds, given its reactivity and ability to form diverse chemical structures. Its presence in the synthesis process can contribute to the creation of innovative drugs with improved efficacy, safety, and pharmacokinetic properties.
Check Digit Verification of cas no
The CAS Registry Mumber 26458-78-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,4,5 and 8 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 26458-78:
(7*2)+(6*6)+(5*4)+(4*5)+(3*8)+(2*7)+(1*8)=136
136 % 10 = 6
So 26458-78-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H12N2/c9-7-8-1-4-10(5-2-8)6-3-8/h1-6H2
26458-78-6Relevant articles and documents
NEW METHOD FOR PREPARATION OF 1-AZABICYCLOOCTANE-4-CARBONITRILE AND 1-AZABICYCLONONANE-5-CARBONITRILE
Svoboda, Jiri,Palecek, Jaroslav
, p. 1536 - 1540 (1995)
The title compounds were prepared from pyridine-4-carboxamide.Its alkylation with 2-chloroethanol or 3-chloropropanol, followed by hydrogenation gave 1-substituted piperidine-4-carboxamides IIIa and IIIb, respectively, which on treatment with thionyl chloride were converted into the respective 1-substituted halogenoalkylpiperidine-4-carbonitriles IVa and IVb.On cyclization, compounds IVa and IVb afforded 1-azabicyclooctane-4-carbonitrile and 1-azabicyclononane-5-carbonitrile, respectively.
Pleuromutilin derivatives as antimicrobials
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, (2008/06/13)
The present invention relates to pleuromutilin derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medical therapy, particularly antibacterial therapy.
4-cyanopiperidine derivatives, preparation and use thereof
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, (2008/06/13)
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