265664-80-0

Basic information

• Product Name: {4-[(4-nitro-1H-pyrrole-2-carbonyl)-amino]-benzyl}-carbamic acid tert-butyl ester
• Synonyms: {4-[(4-nitro-1H-pyrrole-2-carbonyl)-amino]-benzyl}-carbamic acid tert-butyl ester
• CAS NO: 265664-80-0
• Molecular Weight: 360.37
• Mol File: 265664-80-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {4-[(4-nitro-1H-pyrrole-2-carbonyl)-amino]-benzyl}-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {4-[(4-nitro-1H-pyrrole-2-carbonyl)-amino]-benzyl}-carbamic acid tert-butyl ester(265664-80-0)
• EPA Substance Registry System: {4-[(4-nitro-1H-pyrrole-2-carbonyl)-amino]-benzyl}-carbamic acid tert-butyl ester(265664-80-0)

Safety Data

• Hazardous Substances Data: 265664-80-0(Hazardous Substances Data)

Upstream product

• 94838-58-1 tert-butyl 4-nitrobenzylcarbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 13138-74-4 methyl 4-nitropyrrole-2-carboxylate 
• 5930-93-8 4-nitropyrrole-2-carboxylic acid 
• 94838-55-8 tert-butyl (4-aminobenzyl)carbamate 
• 7409-30-5 p-nitrobenzylamine 
• 619-72-7 4-nitrobenzonitrile 

Downstream Products

• 265664-83-3 [4-({4-[4-(tert-butoxycarbonylamino-methyl)-benzoylamino]-1H-pyrrole-2-carbonyl}-amino)-benzyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Synthesis, DNA binding, topoisomerases inhibition and cytotoxic properties of 4-arylcarboxamidopyrrolo-2-carboxyanilides

Three 4-arylcarboxamidopyrrolo-2-carboxyanilides bearing different substituents on the pyrrole nitrogen were synthesized and evaluated for their capacities to bind to specific sequences within the minor groove of DNA and to inhibit human topoisomerases I and II in vitro. The cytotoxicity of the drugs correlates with their DNA binding affinities. The two drugs bearing a N-methyl or N-benzyl pyrrole stabilize topoisomerase I-DNA complexes. (C) 2000 Elsevier Science Ltd. All rights reserved.