269061-92-9Relevant articles and documents
Phosphonic acid analogs of diclofenac: An Arbuzov reaction of trimethylphosphite with an ortho-quinonoid intermediate
Mugrage, Ben,Diefenbacher, Clive,Somers, Joe,Parker, David T.,Parker, Tonia
, p. 2047 - 2050 (2007/10/03)
The phosphonic acid analog of the NSAID Diclofenac was efficiently synthesized via an Arbuzov reaction between 2-(2,6-dichloroanilino)benzyl alcohol and trimethyl phosphite followed by TMSBr promoted dealkylation. Seven related phosphonic acids were synth