26946-72-5

Basic information

• Product Name: N-(4-nitrophenyl)-1,3-benzoxazol-2-amine
• Synonyms: N-(4-nitrophenyl)-1,3-benzoxazol-2-amine
• CAS NO: 26946-72-5
• Molecular Weight: 255.233
• Mol File: 26946-72-5.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: N-(4-nitrophenyl)-1,3-benzoxazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-nitrophenyl)-1,3-benzoxazol-2-amine(26946-72-5)
• EPA Substance Registry System: N-(4-nitrophenyl)-1,3-benzoxazol-2-amine(26946-72-5)

Safety Data

• Hazardous Substances Data: 26946-72-5(Hazardous Substances Data)

Upstream product

• 13673-62-6 2-methylsulfanyl-benzoxazole 
• 100-01-6 4-nitro-aniline 
• 1056477-06-5 2-bromocyclohexanone 
• 556-10-5 p-nitrophenylurea 
• 108-94-1 cyclohexanone 
• 13037-40-6 N-(4-nitrophenyl)methyldithiocarbamic acid 
• 95-55-6 2-amino-phenol 
• 273-53-0 benzoxazole 
• 2131-61-5 p-nitrophenyl isothiocyanate 
• 107368-17-2 1-(2-hydroxyphenyl)-3-(4-nitrophenyl)thiourea 
• 615-18-9 2-chloro-1,3-benzoxazole 

Downstream Products

• 133929-17-6 N¹-(benzo[d]oxazol-2-yl)benzene-1,4-diamine 
• 39223-77-3 2-(4-isothiocyanatophenylamino)benzoxazole 

Relevant articles and documents

Environment-friendly and efficient synthesis of 2-aminobenzo-xazoles and 2-aminobenzothiazoles catalyzed by: Vitreoscilla hemoglobin incorporating a cobalt porphyrin cofactor

In this study, an environment-friendly and efficient artificial Vitreoscilla hemoglobin (VHb) for the synthesis of 2-aminobenzoxazoles and 2-aminobenzothiazoles has been reported. We demonstrate an expression-based porphyrin substitution strategy to produce VHb containing cobalt porphyrin instead of native hemin, which can catalyze the oxidative cyclization of corresponding 2-aminobenzoxazoles and 2-aminobenthiazoles with up to 97% yield and 4850 catalytic turnovers in water under aerobic conditions. Hence, we provide a green and mild method for the synthesis of 2-aminobenzoxazoles and 2-aminobenzothiazoles. In addition, we indicate the value of porphyrin ligand substitution as a strategy to tune and enhance the catalytic properties of hemoproteins in non-natural reactions.

A Cu2O/TBAB-promoted approach to synthesize heteroaromatic 2-Amines: Via one-pot cyclization of aryl isothiocyanates with ortho-substituted amines in water

An efficient approach to synthesize heteroaromatic 2-Amines from one-pot desulfurization/dehydrogenative cyclization of aryl isothiocyanates with ortho-substituted amines in water was developed. This approach tolerated a wide range of functional groups on

Application of cuprous complex containing ortho-position carborane Schiff base ligand

The invention relates to an application of a cuprous complex containing an ortho-position carborane Schiff base ligand, and a structural formula of the cuprous complex is shown in the specification, in the formula, Ar is aryl containing a benzene ring or heterocyclic aryl, and . is a boron hydrogen bond; the cuprous complex is used for catalyzing an oxidative coupling reaction of benzoxazole and amine compounds to synthesize 2-amino benzoxazole derivatives. The preparation method specifically comprises the following steps: dissolving a cuprous complex, benzoxazole and an amine compound in an organic solvent, then reacting with an oxidant at 50-80 DEG C for 6-12 hours, and separating and purifying to obtain the 2-amino benzoxazole derivative. Compared with the prior art, the cuprous complexcontaining the ortho-carborane Schiff base ligand can efficiently catalyze oxidative coupling of benzoxazole and primary amine or secondary amine to synthesize the 2-amino benzoxazole derivative; theproduct has the advantages of good selectivity, low catalyst dosage, mild reaction conditions, high reaction rate, high yield, wide substrate range and the like, and shows a wide industrial application prospect.