26958-67-8Relevant articles and documents
Ruthenium-catalyzed synthesis of 1,3,5-triazin-2(1: H)-ones and dihydro[1,3,5]triazino[1,2- a] benzimidazoles from alcohols and guanides
Zeng, Ming,Xie, Zhong Pao,Cui, Dong-Mei,Zhang, Chen
, p. 11905 - 11907 (2018)
An efficient ruthenium-catalyzed synthesis of tri-substituted 1,3,5-triazinones from alcohols and guanylureas under mild conditions has been developed. The scope of both the alcohols and guanylureas in the reaction is demonstrated. This ruthenium-catalyzed ring-forming process can be successfully extended to 2-guanidinobenzimidazoles to afford substituted dihydro[1,3,5]triazino[1,2-a]benzimidazoles.
Synthesis of novel fused pyrimidines and imidazoles as potential analgesics from 2-amino-4-substituted-striazino[1,2-a]-benzimidazoles
El-Feky, Said A.,Thabet, Hamdy Kh.,Mudawi, Mahmoud M. E.
, p. 709 - 718 (2015/10/28)
The synthesis of novel fused pyrimidines and imidazole derivatives from 2-amino-s-triazino[1,2-a]benzimidazoles 2a-e and 3a-c was successfully carried out by a ring annelation reaction in a very good yield. Compound 3c was screened for analgesic activity against acetic acid irritation and has shown protection equal to the reference drug (diclofenac sodium). The acute toxicity study revealed that compound 3c is safe up to 300 mg/kg and there is no sign and symptoms of toxicity and mortality for 72 hours.
Cyanic Acid Esters. 31. Reactions of 2-Guanidino-benzimidazole with Electrophilic Compounds
Martin, Dieter,Graubaum, Heinz,Kempter, Gerhard,Ehrlichmann, Werner
, p. 303 - 310 (2007/10/02)
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