269726-74-1 Usage
General Description
BOC-(R)-3-AMINO-4-(3-TRIFLUOROMETHYL-PHENYL)-BUTYRIC ACID is a compound that consists of a butyric acid core with an amino group at the third position and a trifluoromethylphenyl group at the fourth position. The BOC prefix indicates that the amino group is protected by a tert-butyloxycarbonyl (BOC) group, which is commonly used in peptide synthesis to prevent unwanted reactions. BOC-(R)-3-AMINO-4-(3-TRIFLUOROMETHYL-PHENYL)-BUTYRIC ACID is important in the field of medicinal chemistry and drug development due to its potential as a building block for the synthesis of pharmaceuticals targeting specific biological processes. Its structure and functional groups make it a versatile starting material for the creation of novel compounds with potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 269726-74-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,9,7,2 and 6 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 269726-74:
(8*2)+(7*6)+(6*9)+(5*7)+(4*2)+(3*6)+(2*7)+(1*4)=191
191 % 10 = 1
So 269726-74-1 is a valid CAS Registry Number.
InChI:InChI=1/C16H20F3NO4/c1-15(2,3)24-14(23)20-12(9-13(21)22)8-10-5-4-6-11(7-10)16(17,18)19/h4-7,12H,8-9H2,1-3H3,(H,20,23)(H,21,22)/t12-/m1/s1
269726-74-1Relevant articles and documents
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Xu, Jinyou,Ok, Hyun O.,Gonzalez, Edward J.,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 4759 - 4762 (2007/10/03)
Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively).
