269726-77-4 Usage
General Description
Boc-(R)-3-Amino-4-(4-trifluoromethyl-phenyl)-butyric acid is a chemical compound with the molecular formula C16H20F3NO4. It is composed of an amino acid derivative with a trifluoromethyl group attached to a phenyl ring. This chemical is often utilized in the pharmaceutical industry as a building block for the synthesis of various organic compounds and pharmaceutical drugs. The Boc group attached to the nitrogen atom provides protection for the amine group during chemical reactions, allowing for selective functionalization of the other parts of the molecule. Boc-(R)-3-Amino-4-(4-trifluoromethyl-phenyl)-butyric acid is commonly used in the development of potential drug candidates due to its structural properties and reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 269726-77-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,9,7,2 and 6 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 269726-77:
(8*2)+(7*6)+(6*9)+(5*7)+(4*2)+(3*6)+(2*7)+(1*7)=194
194 % 10 = 4
So 269726-77-4 is a valid CAS Registry Number.
InChI:InChI=1/C16H20F3NO4/c1-15(2,3)24-14(23)20-12(9-13(21)22)8-10-4-6-11(7-5-10)16(17,18)19/h4-7,12H,8-9H2,1-3H3,(H,20,23)(H,21,22)/t12-/m1/s1
269726-77-4Relevant articles and documents
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Xu, Jinyou,Ok, Hyun O.,Gonzalez, Edward J.,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 4759 - 4762 (2007/10/03)
Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively).
