270065-83-3 Usage
General Description
BOC-(S)-3-Amino-4-(2-cyano-phenyl)-butyric Acid is a specific type of chemical compound known as a protected amino acid. Amino acids are essential building blocks of both proteins and peptides; they play crucial roles in many biological processes, such as nutrient absorption and muscle tissue repair. The "BOC" in its name refers to the tert-butyloxycarbonyl group added to the amino acid to protect it from reacting with other constituents. The "cyano-phenyl" signifies the presence of a cyanophenyl group, a carbon-structured ring with a nitrile group attached, important in many pharmaceutical compounds. This particular compound can be utilized as a reagent in the synthesis of various peptides and is useful in the field of pharmaceutical research.
Check Digit Verification of cas no
The CAS Registry Mumber 270065-83-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,0,0,6 and 5 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 270065-83:
(8*2)+(7*7)+(6*0)+(5*0)+(4*6)+(3*5)+(2*8)+(1*3)=123
123 % 10 = 3
So 270065-83-3 is a valid CAS Registry Number.
InChI:InChI=1/C16H20N2O4/c1-16(2,3)22-15(21)18-13(9-14(19)20)8-11-6-4-5-7-12(11)10-17/h4-7,13H,8-9H2,1-3H3,(H,18,21)(H,19,20)/t13-/m0/s1
270065-83-3Relevant articles and documents
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Xu, Jinyou,Ok, Hyun O.,Gonzalez, Edward J.,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 4759 - 4762 (2007/10/03)
Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively).
