270078-94-9

Basic information

• Product Name: (R,R)-2,2'-isopropylidenebis(4-(diphenylmethyl)oxazoline)
• Synonyms: (R,R)-2,2'-isopropylidenebis(4-(diphenylmethyl)oxazoline)
• CAS NO: 270078-94-9
• Molecular Weight: 514.667
• Mol File: 270078-94-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R,R)-2,2'-isopropylidenebis(4-(diphenylmethyl)oxazoline)(CAS DataBase Reference)
• NIST Chemistry Reference: (R,R)-2,2'-isopropylidenebis(4-(diphenylmethyl)oxazoline)(270078-94-9)
• EPA Substance Registry System: (R,R)-2,2'-isopropylidenebis(4-(diphenylmethyl)oxazoline)(270078-94-9)

Safety Data

• Hazardous Substances Data: 270078-94-9(Hazardous Substances Data)

Upstream product

• 270078-93-8 (R,R)-N,N'-bis(2-chloro-1-(diphenylmethyl)ethyl)-2,2-dimethylmalonamide 
• 170937-75-4 (S)-N-tert-butoxycarbonyl-4-(hydroxydiphenylmethyl)-2,2-dimethyloxazolidine 
• 7321-55-3 2,2-dimethylmalononitrile 
• 171037-01-7 (R)-2-amino-3,3-diphenyl-1-propanol 

Relevant articles and documents

Chemo- and Enantioselective Intramolecular Silver-Catalyzed Aziridinations

Asymmetric nitrene-transfer reactions are a powerful tool for the preparation of enantioenriched amine building blocks. Reported herein are chemo- and enantioselective silver-catalyzed aminations which transform di- and trisubstituted homoallylic carbamates into [4.1.0]-carbamate-tethered aziridines in good yields and with ee values of up to 92 %. The effects of the substrate, silver counteranion, ligand, solvent, and temperature on both the chemoselectivity and ee value were explored. Stereochemical models were proposed to rationalize the observed absolute stereochemistry of the aziridines, which undergo nucleophilic ring opening to yield enantioenriched amines with no erosion in stereochemical integrity.