27022-64-6

Basic information

• Product Name: N-(4-((4-methylphenyl)sulfonamido)phenyl)acetamide
• Synonyms: N-(4-((4-methylphenyl)sulfonamido)phenyl)acetamide
• CAS NO: 27022-64-6
• Molecular Formula: C₁₅H₁₆N₂O₃S
• Molecular Weight: 304.36414
• Mol File: 27022-64-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 184 °C
• Appearance: /
• Density: 1.335±0.06 g/cm3(Predicted)
• PKA: 8.88±0.10(Predicted)
• CAS DataBase Reference: N-(4-((4-methylphenyl)sulfonamido)phenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-((4-methylphenyl)sulfonamido)phenyl)acetamide(27022-64-6)
• EPA Substance Registry System: N-(4-((4-methylphenyl)sulfonamido)phenyl)acetamide(27022-64-6)

Safety Data

• Hazardous Substances Data: 27022-64-6(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 106-50-3 1,4-phenylenediamine 
• 27514-08-5 N-(4-oxocyclohexyl)acetamide 
• 70-55-3 toluene-4-sulfonamide 
• 104-04-1 N-(4-Nitrophenyl)acetamide 
• 824-79-3 sodium 4-methylbenzenesulfinate 

Downstream Products

• 77167-21-6 N-{4-[Oxiranylmethyl-(toluene-4-sulfonyl)-amino]-phenyl}-acetamide 
• 77166-91-7 N-{4-[{3-[4-(4-Chloro-phenyl)-piperazin-1-yl]-2-hydroxy-propyl}-(toluene-4-sulfonyl)-amino]-phenyl}-acetamide 

Relevant articles and documents

Iron-catalyzed N -arylsulfonamide formation through directly using nitroarenes as nitrogen sources

One-step, catalytic synthesis of N-arylsulfonamides via the construction of N-S bonds from the direct coupling of sodium arylsulfinates with nitroarenes was realized in the presence of FeCl2 and NaHSO3 under mild conditions. In this process, stable and readily available nitroarenes were used as nitrogen sources, and NaHSO3 acted as a reductant to provide N-arylsulfonamides in good to excellent yields. A broad range of functional groups were very well-tolerated in this reaction system. In addition, mechanistic studies indicated that the N-S bond might be generated through direct coupling of nitroarene with sodium arylsulfinate prior to the reduction of nitroarenes by NaHSO3. Accordingly, a reaction mechanism involving N-aryl-N-arenesulfonylhydroxylamine as an intermediate was proposed.

Synthesis of Oxindoles through the gold-catalyzed oxidation of N-arylynamides

α-Oxo gold carbenoids generated by the oxidation of N-arylynamides can be trapped intramolecularly at the ortho position of the aryl ring to give functionalized oxindoles under mild reaction conditions. Pyridine N-oxide works as the oxidant, ligand, and base in this transformation. Copyright