27058-83-9 Usage
Description
2-Amino-4-chlorobenzothiazole hydrobromide is a synthetic organic compound with the molecular formula C7H7BrN2S. It is a white to off-white crystalline powder that is soluble in water. This chemical is commonly used in research and in the pharmaceutical industry as an intermediate in the synthesis of various pharmaceuticals and organic compounds. It has the potential to exhibit biological activity and may be used as a building block in the development of pharmaceutical drugs.
Uses
Used in Pharmaceutical Industry:
2-Amino-4-chlorobenzothiazole hydrobromide is used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. Its potential biological activity makes it a valuable building block in the development of pharmaceutical drugs.
Used in Research:
2-Amino-4-chlorobenzothiazole hydrobromide is used in research for its potential biological activity and as a starting material for the synthesis of various compounds. Its solubility in water makes it useful in various laboratory applications.
Used in Organic Synthesis:
2-Amino-4-chlorobenzothiazole hydrobromide is used as a starting material in the synthesis of various organic compounds. Its unique chemical structure allows for the formation of a wide range of products through chemical reactions.
Used in Laboratory and Industrial Applications:
2-Amino-4-chlorobenzothiazole hydrobromide is used in various laboratory and industrial applications due to its solubility in water and its potential for use in the synthesis of pharmaceuticals and organic compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 27058-83-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,0,5 and 8 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 27058-83:
(7*2)+(6*7)+(5*0)+(4*5)+(3*8)+(2*8)+(1*3)=119
119 % 10 = 9
So 27058-83-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H5ClN2S.BrH/c8-4-2-1-3-5-6(4)10-7(9)11-5;/h1-3H,(H2,9,10);1H
27058-83-9Relevant articles and documents
Synthesis, cytotoxic evaluation, and in silico studies of substituted N-alkylbromo-benzothiazoles
Gill, Rupinder Kaur,Singh, Gagandeep,Sharma, Anuradha,Bedi,Saxena
, p. 4211 - 4222 (2013/09/02)
In efforts to develop a new class of anticancer agents with improved efficacy and selective action, a series of N-alkylbromo-benzothiazoles were synthesized and evaluated for in vitro cytotoxic activity against various human cancer cell lines such as lung (A-549), prostate (PC-3), leukemia (THP-1), and colon (Caco-2). They were found to be highly active against prostate (PC-3) and leukemia (THP-1) cancer cells, moderately active against colon (Caco-2) cancer cells and less active against lung (A-549) cancer cells. Of the 12 compounds, two (11d, 11j) exhibit IC50 values of ≤ 1 μM against leukemia (THP-1) cancer cell lines. Compound 11l showed significant cytotoxic activity against the PC-3 (IC50 = 0.6 μM), THP-1 (IC50 = 3 μM) and Caco-2 cell lines (IC50 = 9.9 μM), respectively. Docking study of the synthesized ligand was done on epidermal growth factor receptor using ArgusLab flexible docking, to determine their observed activity. Further QSAR investigations with stepwise multiple linear regression analysis were applied to find correlation between various physicochemical parameters and anticancer activity. The QSAR results showed that anticancer activity could be modeled with descriptors. The predictive ability of models was cross-validated by observation of the low residual activity values and adjusted coefficient of variation (radj2) obtained by leave-one-out technique.
