2708-77-2 Usage
Description
4-FLUORO-DL-GLUTAMIC ACID is an amino acid derivative with a fluorine atom substitution at the 4th position. It is a key component in the synthesis of various pharmaceutical compounds and serves as a valuable tool in the medical field for diagnostic purposes.
Uses
Used in Pharmaceutical Synthesis:
4-FLUORO-DL-GLUTAMIC ACID is used as a reagent for the synthesis of analogues of Methotrexate (M260675), a drug that is utilized in the treatment of acute leukemia, breast carcinoma, and rheumatoid arthritis. Its unique structure allows for the development of novel therapeutic agents with potential improvements in efficacy and safety.
Used in Medical Imaging:
In the medical field, the labelled form of 4-FLUORO-DL-GLUTAMIC ACID is employed as an amino acid radiotracer for the imaging of tumors. This application aids in the detection and monitoring of cancerous growths, providing valuable information for diagnosis and treatment planning.
Check Digit Verification of cas no
The CAS Registry Mumber 2708-77-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,7,0 and 8 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 2708-77:
(6*2)+(5*7)+(4*0)+(3*8)+(2*7)+(1*7)=92
92 % 10 = 2
So 2708-77-2 is a valid CAS Registry Number.
InChI:InChI=1/C5H8FNO4/c6-2(4(8)9)1-3(7)5(10)11/h2-3H,1,7H2,(H,8,9)(H,10,11)/t2?,3-/m0/s1
2708-77-2Relevant articles and documents
Chemistry of 4-fluoroglutamic acid. Part 2. Separation of the diastereomers on a large scale. Preparation of cis- and trans-4-fluoro-5-pyrrolidone-2-carboxylic acids (4-fluoropyroglutamic acids)
Tolman, V.,Vlasakova, V.,Nemecek, J.
, p. 185 - 191 (2007/10/02)
Separation of the 4-fluoroglutamic acid diastereomers has been achieved by crystalization of the hydrochlorides of their dialkyl esters 1b and 2d.Subsesquent hydrolysis afforded the diastereomers 1a and 2a in 100percent steric purity.Conversion of the acids into the 5-methyl esters followed by treatment with ammonia gives rise to the trans and cis isomers of 4-fluoro-5-pyrrolidine-2-carboxylic acid, 3 and 4.NMR data are given.
Fluorine-ocntaining amino acids and their derivatives. 7.1 Synthesis and antitumor activity α- and γ-substituted methotrexate analogs
Tsushima,Kawada,Ishihara,Uchida,Shiratori,Higaki,Hirata
, p. 5375 - 5387 (2007/10/02)
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