27080-08-6

Basic information

• Product Name: 4,4'-Biquinoline
• Synonyms: [4,4']Bichinolyl;[4,4']biquinolinyl;4,4‘-Biquinoline;4,4'-Diquinolyl;4,4'-biquinoline
• CAS NO: 27080-08-6
• Molecular Formula: C18H12N2
• Molecular Weight: 256.307
• Mol File: 27080-08-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4,4'-Biquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-Biquinoline(27080-08-6)
• EPA Substance Registry System: 4,4'-Biquinoline(27080-08-6)

Safety Data

• Hazardous Substances Data: 27080-08-6(Hazardous Substances Data)

Upstream product

• 1613-37-2 Quinoline N-oxide 
• 79476-06-5 4-trimethylstannyl-quinoline 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 75-36-5 acetyl chloride 
• 98-88-4 benzoyl chloride 
• 79-03-8 propionyl chloride 
• 16560-43-3 4-iodoquinoline 
• 5764-82-9 bromo(2-ethoxy-2-oxoethyl)zinc 
• 611-35-8 4-chloroquinoline 

Relevant articles and documents

Anion-radical 1,4-transition of oxygen in the quinoline-N-oxides

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Studies on Pyrimidine Derivatives. XXXVIII. Cross-Coupling Reaction of N-Heteroaryl Iodides with Ethoxycarbonylmethylzinc Bromide in the Presence of Palladium Catalyst

In the presence of tetrakis(triphenylphosphine)palladium, 2-iodo-4,6-dimethylpyrimidine and 4-iodo-2,6-dimethylpyrimidine reacted with ethoxycarbonylmethylzinc bromide (Reformatsky reagent) to give ethyl 4,6-dimethyl-2-pyrimidineacetate and ethyl 2,6-dimethyl-4-pyrimidineacetate, respectively.In contrast, the reaction of 5-iodo-2,4-dimethylpyrimidine with the same reagent resulted in recovery of the starting iodide.Similar results were observed in the reactions of various N-heteroaryl iodides.Keywords - Reformatsky reagent; cross-coupling reaction; N-heteroaryl halide; N-heteroarylacetic acid; palladium catalyst; ethyl bromoacetate

Studies on Organometallic Compounds. III. Reaction of Trimethylstannylazines with Acyl Chlorides. A Novel C-C Bond Formation of Pyridine Nuclei

Introduction of an acyl group at the α-, β-, and γ-positions of pyridine nuclei was accomplished. 2-Trimethylstannyl-pyridine and -quinoline and 1-trimethylstannylisoquinoline directly reacted with various acyl chlorides to give the corresponding 2-pyridyl, 2-quinolyl, and 1-isoquinolyl ketones, respectively.Reaction of 3-trimethylstannylpyridine, -quinoline, and -isoquinoline with acyl chlorides proceeded smoothly under catalysis by PdCl2 or PdCl2(PPh3)2 to afford the corresponding ketones in good yields.Similary, 4-pyridyl, -quinolyl, and -isoquinolyl ketones were prepared from corresponding 4-trimethylstannyl derivatives and acyl chlorides.Keywords--trimethylstannylazine; palladium-catalyzed reaction; acylation; palladium dichloride; dichlorobis(triphenylphosphine)palladium(II)