27087-06-5

Basic information

• Product Name: 5-chloro-6-nitro-3H-benzooxazol-2-one
• Synonyms: 5-chloro-6-nitro-3H-benzooxazol-2-one
• CAS NO: 27087-06-5
• Molecular Formula: C₇H₃ClN₂O₄
• Molecular Weight: 214.57
• Mol File: 27087-06-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 1.704 g/cm³
• Refractive Index: 1.646
• CAS DataBase Reference: 5-chloro-6-nitro-3H-benzooxazol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-6-nitro-3H-benzooxazol-2-one(27087-06-5)
• EPA Substance Registry System: 5-chloro-6-nitro-3H-benzooxazol-2-one(27087-06-5)

Safety Data

• Hazardous Substances Data: 27087-06-5(Hazardous Substances Data)

Usage

General Description

5-chloro-6-nitro-3H-benzooxazol-2-one, also known as Nifuratel, is a chemical compound that is used in the pharmaceutical industry as an antimicrobial and antiprotozoal agent. It is commonly used in the treatment of bacterial and fungal infections in the urinary and gastrointestinal tracts. Nifuratel works by inhibiting the growth and reproduction of microorganisms, making it effective in treating various types of infections. 5-chloro-6-nitro-3H-benzooxazol-2-one has also been studied for its potential use in the treatment of sexually transmitted infections, making it a versatile and important chemical in the field of medicine.

InChI:InChI=1/C7H3ClN2O4/c8-3-1-4-6(14-7(11)9-4)2-5(3)10(12)13/h1-2H,(H,9,11)

Upstream product

• 95-25-0 5-chloro-2-benzoxazolinone 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 6358-07-2 2-amino-4-chloro-5-nitrophenol 

Downstream Products

• 27087-07-6 6-benzenesulfonylamino-5-chloro-3H-benzooxazol-2-one 
• 27087-09-8 6-benzenesulfonylimino-5-chloro-6H-benzooxazol-2-one 
• 493033-59-3 3-N-benzyl-5-chloro-6-nitro-benzoxazol-2-one 
• 64037-30-5 6-amino-5-chlorobenzo[d]oxazol-2(3H)-one 

Relevant articles and documents

Design, Synthesis and Herbicidal Activities of Tetrahydroisoindoline-1,3-dione Derivatives Containing Alkoxycarbonyl Substituted 2-Benzoxazolinone

Several different alkoxycarbonyl-substituted 2-benzoxazolinone moieties have been incorporated into a tetrahydroisoindoline-1,3-dione scaffold to provide 25 compounds (1a-1u and 2a-2d). The structures of these compounds were confirmed by 1H and 13C NMR, HRMS and X-ray single-crystal diffraction. Some of these compounds (1g, 1h, 1j, 1k) exhibited excellent herbicidal activities against Abutilon theophrasti, Amaranthus retroflexus and Echinochloa crus-galli at a rate of 375 g AI·ha-1. Among them, compounds 1h and 1j displayed the best post-emergence herbicidal effect against Abutilon theophrasti with ED50 values of 1.8 and 5.3 g AI·ha-1, respectively, which are superior to that of the commercial acifluorfen (44.3 g AI·ha-1). Field trials demonstrated that compound 1h exhibited similar herbicidal activity to a high concentration atrazine, and found to be safer for maize than atrazine. The results of this study therefore show that compound 1h could potentially be used as a post-emergence herbicide for maize fields. Two series of tetrahydroisoindoline-1,3-diones containing an alkoxycarbonyl substituted 2-benzoxazolinone moiety were designed and synthesized. Compound 1h displayed excellent herbicidal effect against Abutilon theophrasti with ED50 values of 1.8 g AI·ha-1, and compound 1h could potentially be used as a new post-emergence herbicide for maize fields.

6-Acylamino-5-substituted-benzoxazol-2-one compounds and method for using them

Disclosed is a 6-acylamino-5-substituted-benzoxazol-2-one compound having the structural formula I: wherein Y is halogen or a substituent group linked to the rest of the compound by a hetero atom, and R′ is a group containing at least 8 carbon atoms. Also

Benzothiazol-2-one-3-alkanoic acids and esters and aldose reductase inhibiting compositions thereof

A pharmaceutical composition comprising certain benzothiazoline alkanoic acid derivatives for the prevention and treatment of various diabetic complications, said derivatives being inhibitors of aldose reductase.