27104-72-9Relevant articles and documents
Synthesis and Hofman-degradation of 1-hydroxymethyl-2,2-diemethyl-1,2,3,4-tetrahydroiso-quinolinium-ion
Wiegrebe,Sasse
, p. 145 - 148 (1970)
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Fluorescence “On-Off” chemical sensor for ultrasensitive detection of Al3+ in live cell
Zhu, Jinli,Lu, Linxia,Wang, Miao,Sun, Tongming,Huang, Yang,Wang, Chunxian,Bao, Wenyan,Wang, Minmin,Zou, Fengxia,Tang, Yanfeng
, (2020)
An efficient fluorescent probe, 3, 3-bis(4-hydroxyphenyl)-2-benzofuran-1-one-isoquinoline-1-carbohydrazide hydrazine (L), has been prepared for the selective sensing of Al3+ in DMSO-H2O (90:10, v/v) solution. The 1:2 stoichiometry of
INHIBITORS OF MLH1 AND/OR PMS2 FOR CANCER TREATMENT
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Paragraph 00511-00512, (2021/12/28)
The present invention relates to compounds of Formula (I) that target the MLH1 and/or PMS2 proteins that are components of the DNA Mismatch Repair (MMR) process: Formula (I) wherein R1, R2, R3, R4, R6
A dual-functional fluorescent probe for sequential determination of Cu2+/S2? and its applications in biological systems
Huang, Yu-Ying,Li, Qing-Zhong,Liu, Hai-Bo,Wang, Yang,Wang, Zhi-Gang,Xie, Cheng-Zhi,Xu, Jing-Yuan,Yan, Xiao-Jing
, (2020/08/17)
A new acylhydrazine-derived Schiff base fluorescence probe DMI based on “ON-OFF-ON” fluorescence strategy was presented in this paper. Probe DMI could detect Cu2+ selectively and sensitively with dramatic fluorescence quenching in CH3OH-PBS (v/v = 3:7) mixed solution. Once the complex DMI-Cu2+ interacted with S2?, 10.67-folds fluorescence increase was induced via a displacement mechanism under the same experimental conditions. The corresponding detection limits for Cu2+ and S2? were calculated to be 1.52 × 10?8 M and 1.79 × 10?8 M, respectively. The structures of DMI and DMI-Cu2+ were systematically characterized by Job's plot analysis, ESI-MS, IR, X-ray diffraction and density functional theory calculations. Furthermore, fluorescence imaging in MCF-7 cells and zebrafish demonstrated the probe DMI could act as a useful tool to monitor and track intracellular Cu2+ and S2?, which was encouraged by remarkable fluorescence performance and low cytotoxicity. Importantly, the complex DMI-Cu2+ could be applied to detect corrupt blood samples, which could estimate the time of death.