27164-13-2

Basic information

• Product Name: 5-chloro-3,4-dimethoxy-1-(2-nitrovinyl)benzene
• Synonyms: 5-chloro-3,4-dimethoxy-1-(2-nitrovinyl)benzene
• CAS NO: 27164-13-2
• Molecular Weight: 243.647
• Mol File: 27164-13-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-chloro-3,4-dimethoxy-1-(2-nitrovinyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-3,4-dimethoxy-1-(2-nitrovinyl)benzene(27164-13-2)
• EPA Substance Registry System: 5-chloro-3,4-dimethoxy-1-(2-nitrovinyl)benzene(27164-13-2)

Safety Data

• Hazardous Substances Data: 27164-13-2(Hazardous Substances Data)

Upstream product

• 121-33-5 vanillin 
• 19463-48-0 5-chlorovanillin 
• 75-52-5 nitromethane 
• 18268-68-3 5-chloroveratraldehyde 

Downstream Products

• 67287-36-9 2-(2-chloro-3,4-dimethoxyphenyl)ethylamine 
• 102851-70-7 2-chlorodopamine 

Relevant articles and documents

Chemoselective zinc/HCl reduction of halogenated β-nitrostyrenes: Synthesis of halogenated dopamine analogues

A detailed account regarding the synthesis of 2- and 5-halogenated dopamine is given. The key step is a chemoselective reduction of a nitrostyrene by Zn/HCl at 0 °C. These conditions represent a simple, low-cost alternative to reduction by water-sensitive hydride donors and two-step procedures. Under these conditions, aryl fluoride, chloride, and bromide groups are stable. However, iodine undergoes significant reductive dehalogenation.