2724-66-5 Usage
General Description
"(2,4,6-Trichlorophenyl)hydrazine monohydrochloride" is a chemical compound that is often used in research and manufacturing industries. The term itself designates a specific type of organic compound that includes a phenyl group (the derivative of a benzene ring) as a part of its molecular structure. Moreover, it contains three chlorine atoms (tri-chloro) attached to the phenyl group, located specifically at the 2nd, 4th and 6th carbon positions of a benzene ring. It also features a hydrazine group, which is an organic compound containing two nitrogen atoms. The addition of monohydrochloride to the name signifies there is one (mono-) hydrochloride ion present in the compound. Thus, this chemical has diverse potential applications because of its distinct molecular structure, but also requires careful handling due to its reactive properties.
Check Digit Verification of cas no
The CAS Registry Mumber 2724-66-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,7,2 and 4 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2724-66:
(6*2)+(5*7)+(4*2)+(3*4)+(2*6)+(1*6)=85
85 % 10 = 5
So 2724-66-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H5Cl3N2.ClH/c7-3-1-4(8)6(11-10)5(9)2-3;/h1-2,11H,10H2;1H
2724-66-5Relevant articles and documents
Identification and Structure-Activity Relationships of Diarylhydrazides as Novel Potent and Selective Human Enterovirus Inhibitors
Han, Xin,Sun, Ningyuan,Wu, Haoming,Guo, Deyin,Tien, Po,Dong, Chune,Wu, Shuwen,Zhou, Hai-Bing
supporting information, p. 2139 - 2150 (2016/03/25)
Enterovirus 71 (EV71) plays an important role in hand-foot-and-mouth disease. In this study, a series of diarylhydrazide analogues was synthesized, and the systematic exploration of SAR led to potent enterovirus inhibitors, of which compound 15 exhibits significant improvements in inhibition potency with an EC50 value of 0.02 μM against EV71. It is very interesting that this class of diarylhydrazides exhibits activities against a series of human enteroviruses at the picomolar level, including EV71 and Coxsackieviruses B1 (CVB1), CVB2, CVB3, CVB4, CVB5, and CVB6 (EC50 as low as 0.5 nM). Compared with the reference antienterovirus drug 1 (enviroxime) and known inhibitor 5 (WIN 51711), the four highly selective compounds 15, 27, 41 and 47 inhibited EV71 replication with EC50 values of 0.17-0.02 μM and SI values in a range of 978.4-12338. A preliminary mechanistic study indicated that VP1 might be the target site for this type of compound.
