2728-61-2 Usage
Description
N-(trifluoroacetyl)phenylalanine is a phenylalanine derivative featuring a trifluoroacetyl group attached to its nitrogen atom. This chemical compound is recognized for its role in enhancing the stability and bioavailability of peptide drugs, thanks to the protective effect of the trifluoroacetyl group on the peptide backbone, thereby improving pharmacokinetic properties. Its unique structural properties position it as a valuable asset in medicinal chemistry and pharmaceutical research.
Uses
Used in Pharmaceutical and Biochemical Production:
N-(trifluoroacetyl)phenylalanine is utilized as a building block in the synthesis of peptides and proteins, contributing to the development of pharmaceuticals and biochemicals. Its presence in these compounds aids in the protection from degradation and enhancement of pharmacokinetic properties, which is crucial for drug efficacy and safety.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, N-(trifluoroacetyl)phenylalanine serves as a valuable tool for the study and development of peptide-based drugs. Its unique structural attributes make it instrumental in exploring new drug candidates and optimizing existing ones for better therapeutic outcomes.
Used in Peptide Drug Stability Enhancement:
N-(trifluoroacetyl)phenylalanine is employed as a stabilizing agent for peptide drugs, where its trifluoroacetyl group shields the peptide backbone from degradation, thus improving the drug's stability and bioavailability, which are essential for effective drug delivery and action.
Used in Drug Design and Development:
N-(trifluoroacetyl)phenylalanine is used in the design and development of new pharmaceuticals, particularly in the creation of peptide-based therapeutics. Its incorporation into drug molecules can lead to enhanced pharmacokinetic profiles, making it a key component in the advancement of drug discovery and innovation.
Check Digit Verification of cas no
The CAS Registry Mumber 2728-61-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,7,2 and 8 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 2728-61:
(6*2)+(5*7)+(4*2)+(3*8)+(2*6)+(1*1)=92
92 % 10 = 2
So 2728-61-2 is a valid CAS Registry Number.
2728-61-2Relevant articles and documents
Direct C-H alkylation of naphthoquinones with amino acids through a revisited Kochi-Anderson radical decarboxylation: Trends in reactivity and applications
Naturale, Guillaume,Lamblin, Marc,Commandeur, Claude,Dessolin, Jean,Felpin, Francois-Xavier
supporting information, p. 5774 - 5788,15 (2020/09/15)
In our ongoing research program into the discovery of new anticancer drugs, we were interested in the preparation of naphthoquinone scaffolds bearing aminoalkyl side-chains. Following this aim, we revisited the Kochi-Anderson radical decarboxylation of amino acids in order to set up a versatile route to the direct functionalization of naphthoquinones. The best reaction conditions were applied to a selected series of compounds in a systematic methodological study which allowed us to establish important trends in reactivity. We found that α-substituted β-amino acids were the most suitable substrates for the radical addition. In contrast, α-amino acids gave modest results. The influence of the amine protecting groups on the reaction outcome has also been studied. This practical procedure allows the introduction of various unsymmetrical moieties, including orthogonally protected linear aminoalkyl chains or chiral dipeptidic chains, and opens the door to a wide scope of easily accessible chemical diversity.
Trifluoroacetylation of amino acids under aqueous conditions using a readily prepared non-odoriferous reagent
Hickey, Matthew R.,Nelson, Todd D.,Secord, Elizabeth A.,Allwein, Shawn P.,Kress, Michael H.
, p. 255 - 258 (2007/10/03)
The synthesis of S-dodecyltrifluorothioacetate and its application to trifluoroacetylation of amino acids under aqueous conditions are described. This reagent afforded good isolated yields (71-92%) of the N-trifluoroacetyl derivatives via an operationally simple and odor free procedure.
19 F nuclear magnetic resonance for the control of peptide synthesis.
Bayer,Hunziker,Mutter,Sievers,Uhmann
, p. 265 - 268 (2007/10/12)
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