2732-80-1

Basic information

• Product Name: 3-BROMO-4-CHLOROANISOLE
• Synonyms: 3-BROMO-4-CHLOROANISOLE;4-Chloro-3-Bromoanisole;2-chloro-5-methoxybromobenzene;2-Bromo-1-chloro-4-methoxybenzene, 3-Bromo-4-chlorophenyl methyl ether;2-broMo-1-chloro-4-Methoxybenzene;3-broMo-4-chloroaMizole;Benzene, 2-bromo-1-chloro-4-methoxy-
• CAS NO: 2732-80-1
• Molecular Formula: C₇H₆BrClO
• Molecular Weight: 221.48
• Product Categories: Aromatic Ethers;Anisoles, Alkyloxy Compounds & Phenylacetates;Bromine Compounds;Chlorine Compounds
• Mol File: 2732-80-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 231.9 °C at 760 mmHg
• Flash Point: 94.1 °C
• Appearance: /
• Density: 1.564 g/cm³
• Vapor Pressure: 0.0477mmHg at 25°C
• Refractive Index: 1.556
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform, Ethyl Acetate (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 3-BROMO-4-CHLOROANISOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-4-CHLOROANISOLE(2732-80-1)
• EPA Substance Registry System: 3-BROMO-4-CHLOROANISOLE(2732-80-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-51
• Hazardous Substances Data: 2732-80-1(Hazardous Substances Data)

Usage

Description

3-Bromo-4-chloroanisole is an organic compound that serves as a valuable synthetic intermediate in the chemical industry. It is characterized by the presence of a bromine atom at the 3rd position and a chlorine atom at the 4th position on the anisole molecule, which contributes to its unique chemical properties and reactivity.

Uses

Used in Chemical Synthesis:
3-Bromo-4-chloroanisole is used as a synthetic intermediate for the production of various organic compounds. Its unique structure allows it to be a key component in the synthesis of complex molecules.
Used in the Synthesis of N-heterocycle-fused Phenanthridines:
3-Bromo-4-chloroanisole is used as a starting material for the synthesis of N-heterocycle-fused phenanthridines, which are blue-emitting luminophores. These luminophores have potential applications in the development of advanced materials for optoelectronic devices, such as organic light-emitting diodes (OLEDs) and other display technologies.
Used in the Preparation of Indoles:
3-Bromo-4-chloroanisole is also utilized in the preparation of indoles, specifically through a Pd-catalyzed cascade process. Indoles are important structural motifs found in numerous biologically active compounds, including pharmaceuticals, agrochemicals, and natural products. The synthesis of indoles using 3-bromo-4-chloroanisole can lead to the development of new and innovative indole-based molecules with potential applications in various industries.

InChI:InChI=1/C7H6BrClO/c1-10-5-2-3-7(9)6(8)4-5/h2-4H,1H3

Upstream product

• 2401-24-3 2-chloro-5-methoxyaniline 
• 13659-24-0 3-bromo-4-chlorophenol 
• 77-78-1 dimethyl sulfate 
• 50586-69-1 2,3,6-tribromo-4-chloro-phenol 
• 10298-80-3 2-chloro-5-methoxynitrobenzene 
• 96-96-8 4-methoxy-2-nitroaniline 
• 74-88-4 methyl iodide 

Downstream Products

• 939771-49-0 1-chloro-2-(4-fluorophenoxy)-4-methoxybenzene 
• 939771-48-9 4-chloro-3-(4-fluorophenoxy)phenol 
• 13659-24-0 3-bromo-4-chlorophenol 
• 1131890-63-5 (E)-5-methoxy-1-phenyl-2-styryl-1H-indole 
• 1227188-08-0 2-chloro-N-(2,6-diisopropylphenyl)-5-methoxyaniline 
• 1259658-97-3 1,2-diphenyl-5-methoxy-1H-indole 
• 6280-89-3 2-chloro-5-methoxybenzoic acid 
• 1284229-85-1 2-methoxy-5-(4-methoxyphenyl)-5,6,6a,7,8,9-hexahydrophenanthridine 
• 1284230-22-3 (R)-2-methoxy-5-(4-methoxyphenyl)-5,6,6a,7,8,9-hexahydrophenanthridine 
• 1331753-60-6 (2-(2-chloro-5-methoxyphenoxy)phenyl)(phenyl)methanone 
• 1331753-37-7 7-methoxy-11-phenyldibenzo[b,f][1,4]oxazepine 
• 1350629-01-4 1-phenyl-2-(4-N,N-dimethylamino-phenyl)-1H-5-methoxy-benzo[d]imidazole 
• 1350629-08-1 5-methoxy-1,2-diphenyl-1H-benzo[d]imidazole 
• 1354786-50-7 5-Chloro-4-[(6-chloro-2'-fluoro-4-pyridazin-4-ylbiphenyl-3-yl)oxy]-2-fluoro-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide 

Relevant articles and documents

ARYLMETHYLENE HETEROCYCLIC COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS

A compound of Formula (I) or a pharmaceutically acceptable salt thereof is described, wherein the substituents are as defined herein. Pharmaceutical compositions comprising the same and method of using the same are also described.