27376-74-5

Basic information

• Product Name: 13,14-DIHYDRO PROSTAGLANDIN F2ALPHA
• Synonyms: 13,14-dihydro PGF2a;(5Z,15S)-9α,11α,15-Trihydroxyprosta-5-ene-1-oic acid;(5Z,9α,11α,15S)-9,11,15-Trihydroxyprosta-5-ene-1-oic acid;13,14-Dihydro-PGF2α;13,14-Dihydroprostaglandin F2α;9ALPHA,11ALPHA,15S-TRIHYDROXY-PROST-5Z-EN-1-OIC ACID;13,14-DIHYDRO PROSTAGLANDIN F2ALPHA;13,14-dihydrodinoprost
• CAS NO: 27376-74-5
• Molecular Formula: C20H36O5
• Molecular Weight: 356.5
• Mol File: 27376-74-5.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 547.1 ºC at 760 mmHg
• Flash Point: 298.8 ºC
• Appearance: /
• Density: 1.095 g/cm³
• Vapor Pressure: 2.98E-14mmHg at 25°C
• Refractive Index: 1.52
• CAS DataBase Reference: 13,14-DIHYDRO PROSTAGLANDIN F2ALPHA(CAS DataBase Reference)
• NIST Chemistry Reference: 13,14-DIHYDRO PROSTAGLANDIN F2ALPHA(27376-74-5)
• EPA Substance Registry System: 13,14-DIHYDRO PROSTAGLANDIN F2ALPHA(27376-74-5)

Safety Data

• Hazardous Substances Data: 27376-74-5(Hazardous Substances Data)

Usage

Description

13,14-Dihydro Prostaglandin F2α (13,14-Dihydro PGF2α) is an analog of Prostaglandin F2α (PGF2α), characterized by the absence of unsaturation in the lower side chain. It is a prostaglandin Falpha derivative, with prost-5-en-1-oic acid substituted by hydroxy groups at positions 9, 11, and 15. 13,14-DIHYDRO PROSTAGLANDIN F2ALPHA exhibits a higher potency in inducing luteolysis in hamsters compared to PGF2α.

Uses

Used in Pharmaceutical Applications:
13,14-Dihydro PGF2α is used as a luteolytic agent for inducing luteolysis in hamsters and rabbits. It demonstrates a potency five times higher than that of PGF2α, making it a more effective compound for this purpose. The ED50 value for 13,14-dihydro PGF2α as a luteolytic agent in hamsters is 1.5 μg/100 g.
Used in Veterinary Medicine:
In the veterinary industry, 13,14-Dihydro PGF2α is used as a luteolytic agent to facilitate luteolysis in animals, such as hamsters and rabbits. This application aids in the management of reproductive cycles and can be particularly useful in breeding programs.
Used in Research and Development:
13,14-Dihydro PGF2α is also utilized in research and development for studying the effects of prostaglandins on reproductive systems and their potential applications in various medical and veterinary contexts. Its higher potency compared to PGF2α makes it a valuable tool for investigating the mechanisms of luteolysis and related biological processes.

InChI:InChI=1/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,15-19,21-23H,2-3,5-6,8-14H2,1H3,(H,24,25)/b7-4+