27443-18-1

Basic information

• Product Name: DI-N-PROPYLPHOSPHINE OXIDE
• Synonyms: DI-N-PROPYLPHOSPHINE OXIDE;Dipropylphosphine oxide
• CAS NO: 27443-18-1
• Molecular Formula: C₆H₁₅OP
• Molecular Weight: 134.16
• Mol File: 27443-18-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: DI-N-PROPYLPHOSPHINE OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: DI-N-PROPYLPHOSPHINE OXIDE(27443-18-1)
• EPA Substance Registry System: DI-N-PROPYLPHOSPHINE OXIDE(27443-18-1)

Safety Data

• Hazardous Substances Data: 27443-18-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H14OP/c1-3-5-8(7)6-4-2/h3-6H2,1-2H3/q+1

Upstream product

• 92587-62-7 butyl dipropylphosphinite 
• 64-17-5 ethanol 
• 81373-58-2 dipropylphosphinous iodide 
• 106-94-5 propyl bromide 
• 762-04-9 phosphonic acid diethyl ester 
• 2234-82-4 1-propylmagnesium chloride 
• 598-02-7 Diethyl phosphate 

Downstream Products

• 867-33-4 dipropylphosphinic acid 
• 41157-34-0 di-n-propylphosphinous chloride 
• 34979-30-1 di-n-propylphosphinic acid anhydride 
• 56641-74-8 di-n-propyl-trichloromethylphosphine 
• 107264-97-1 di-n-propyl-dichloromethylphosphine oxide 
• 1113-11-7 dipropylphosphinyl chloride 
• 145293-06-7 N-benzyl-aminomethyl-di(n-propyl)phosphine oxide 
• 1221726-94-8 (S)-3-(dipropylphosphoryl)-3-phenyl-1-pyrrol-1-yl-propan-1-one 
• 1236226-94-0 (R)-methyl 2-((dipropylphosphoryl)(phenyl)methyl)acrylate 
• 1246465-09-7 C₁₈H₃₂NO₂PS 
• 66232-91-5 di-n-propylphenylphosphine oxide 
• 70464-79-8 (p-Chlorphenyl)dipropylphosphinoxid 
• 55629-04-4 1-(Dipropyl-phosphinoyl)-4-fluoro-benzene 

Relevant articles and documents

A "green" variation of the Hirao reaction: The P-C coupling of diethyl phosphite, alkyl phenyl-H-phosphinates and secondary phosphine oxides with bromoarenes using a P-ligand-free Pd(OAc)2 catalyst under microwave and solvent-free conditions

The P-C coupling of diethyl phosphite, alkyl phenyl-H-phosphinates, diphenylphosphine oxide and dialkylphosphine oxides with bromoarenes may be performed in the presence of a P-ligand-free Pd(OAc)2 catalyst and triethylamine under microwave-assisted (MW) and, in almost all cases, solvent-free conditions to afford diethyl arylphosphonates, alkyl diphenylphosphinates, aryldiphenylphosphine oxides and dialkylphenylphosphine oxides, respectively. This is the "greenest" accomplishment of the well-known Hirao reaction that has now been found to have general application for a broad spectrum of >P(O)H species with different reactivity and a great variety of substituted bromobenzenes. The alkyl phenyl-H-phosphinates were prepared by the MW-promoted alkylation of phenyl-H-phosphinic acid in the absence of any solvent. This journal is the Partner Organisations 2014.

COLD MENTHOL RECEPTOR-1 ANTAGONISTS

The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.

COLD MENTHOL RECEPTOR-1 ANTAGONISTS

The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.