27465-51-6

Basic information

• Product Name: 4'-Ethylpropiophenone
• Synonyms: 1-(4-Ethylphenyl)propanone;Theethylbenzeneacetone;1-Propanone,1-(4-ethylphenyl)-;P-ETHYLPROPIOPHENONE;1-(4-ETHYL-PHENYL)-PROPAN-1-ONE;4'-ETHYLPROPIOPHENONE;4-ETHYLPROPIOPHENONE;ETHYL 4-ETHYLPHENYL KETONE
• CAS NO: 27465-51-6
• Molecular Formula: C₁₁H₁₄O
• Molecular Weight: 162.23
• EINECS: 2017-001-1
• Product Categories: Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Eperisone Hydrochloride Intermediate;Aromatic Propiophenones (substituted);Aromatics
• Mol File: 27465-51-6.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 246 °C
• Flash Point: 103.2 °C
• Appearance: /
• Density: 0.98
• Vapor Pressure: 0.0368mmHg at 25°C
• Refractive Index: 1.5220-1.5260
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4'-Ethylpropiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-Ethylpropiophenone(27465-51-6)
• EPA Substance Registry System: 4'-Ethylpropiophenone(27465-51-6)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 27465-51-6(Hazardous Substances Data)

Usage

Description

4'-Ethylpropiophenone is an organic compound that is a clear colorless liquid. It is an impurity of Eperisone (E565800), which is used as a muscle relaxant and analgesic.

Uses

Used in Pharmaceutical Industry:
4'-Ethylpropiophenone is used as an impurity in the production of Eperisone (E565800) for its muscle relaxant and analgesic properties. It contributes to the overall effectiveness of the drug in providing relief from muscle pain and tension.
Used in Chemical Research:
As a clear colorless liquid, 4'-Ethylpropiophenone can be utilized in various chemical research applications, potentially for the synthesis of other compounds or as a reagent in chemical reactions. Its specific role in research would depend on the requirements of the particular study or experiment.

InChI:InChI=1/C11H14O/c1-3-10-4-6-11(7-5-10)8-9(2)12/h4-7H,3,8H2,1-2H3

Upstream product

• 104037-22-1 [1-(4-ethyl-phenyl)-vinyl]-methyl ether 
• 100-41-4 ethylbenzene 
• 79-03-8 propionyl chloride 
• 123-62-6 propionic acid anhydride 
• 132560-66-8 α-chloro-4-ethylpropiophenone 
• 97-94-9 triethyl borane 
• 1445317-56-5 N-methyl-N-tosyl-p-chlorobenzamide 
• 67-56-1 methanol 
• 33967-18-9 1-(4-ethylphenyl)ethanol 
• 20024-90-2 p-(n-propyl)ethylbenzene 

Downstream Products

• 805951-15-9 α-Amino-4-ethyl-propiophenon 
• 20024-90-2 p-(n-propyl)ethylbenzene 
• 99865-21-1 1-(4-ethylphenyl)propane-1,2-dione 
• 78575-12-9 1-(4-ethyl-phenyl)-propan-1-one oxime 
• 350997-48-7 2-(4-ethyl-phenyl)-3-methyl-quinoline-4-carboxylic acid 
• 64740-36-9 3-(4-ethyl-phenyl)-propionic acid 
• 345221-04-7 t-butyl β-ethyl-β-(p-ethylphenyl)glycidate 
• 103501-94-6 1-(4-Ethyl-phenyl)-propane-1,2-dione 2-oxime 
• 56839-43-1 eperisone hydrochloride 
• 100125-88-0 1-(4-ethyl-phenyl)-2-bromo-propan-1-one 
• 802871-37-0 (+/-)-1-Isopropylamino-1-(4-ethyl-benzoyl)-ethan 
• 27465-56-1 (1RS,2SR)-1-(4-ethyl-phenyl)-2-methylamino-propan-1-ol 
• 78575-45-8 1-(4-Ethyl-phenyl)-propane-1,2-dione dioxime 
• 78158-67-5 2-(4-Ethyl-phenyl)-butyraldehyde 

Relevant articles and documents

Selective electrochemical oxidation of aromatic hydrocarbons and preparation of mono/multi-carbonyl compounds

A selective electrochemical oxidation was developed under mild condition. Various mono-carbonyl and multi-carbonyl compounds can be prepared from different aromatic hydrocarbons with moderate to excellent yield and selectivity by virtue of this electrochemical oxidation. The produced carbonyl compounds can be further transformed into α-ketoamides, homoallylic alcohols and oximes in a one-pot reaction. In particular, a series of α-ketoamides were prepared in a one-pot continuous electrolysis. Mechanistic studies showed that 2,2,2-trifluoroethan-1-ol (TFE) can interact with catalyst species and generate the corresponding hydrogen-bonding complex to enhance the electrochemical oxidation performance. [Figure not available: see fulltext.]

Method for preparing alpha-alkyl substituted ketone compound

The invention relates to a method for preparing an alpha-alkyl substituted ketone compound, which comprises the following steps: preparing a primary alcohol compound and a secondary alcohol compound as raw materials, adding alkali; with a cyclic iridium complex as a catalyst and water as a reaction medium, heating and stirring the mixture and reacting for 10 to 24 hours under the protection of inert gas, and cooling a reaction product to room temperature after the reaction is finished; carrying out reduced pressure distillation and concentration to obtain a crude product, and carrying out column chromatography purification to obtain a series of alpha alkyl substituted ketone compounds. The method is simple to operate, available in raw materials, low in price, high in reaction efficiency and selectivity, good in adaptability to various functional groups and wide in substrate universality; since water is used as a reaction medium to meet the green and environment-friendly requirements, the method is environmentally friendly and is carried out at gram level, so that the potential of industrially synthesizing the alpha alkyl substituted ketone compound is achieved; therefore, The method has expanded application in the fields of medicines, organic synthesis and the like.

Palladium-catalyzed room temperature acylative cross-coupling of activated amides with trialkylboranes

A highly efficient acylative cross-coupling of trialkylboranes with activated amides has been effected at room temperature to give the corresponding alkyl ketones in good to excellent yields by using 1,3-bis(2,6-diisopropyl)phenylimidazolylidene and 3-chloropyridine co-supported palladium chloride, the PEPPSI catalyst, in the presence of K2CO3 in methyl tert-butyl ether. The scope and limitations of the protocol were investigated, showing good tolerance of acyl, cyano, and ester functional groups in the amide counterpart while halo group competed via the classical Suzuki coupling. The trialkylboranes generated in situ by hydroboration of olefins with BH3 or 9-BBN performed similarly to those separately prepared, making this protocol more practical.