276695-07-9Relevant articles and documents
2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)one derivatives
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, (2008/06/13)
This invention provides compounds of formula I, wherein R is hydrogen or alkyl of 1-6 carbon atoms; R′ is hydrogen, alkyl of 1-6 carbon atoms, acyl of 2-7 carbon atoms, or aroyl; R1, R2, R3, and R4are each, inde
Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-Tetrahydro-1H-pyrazino[1,2-a]quinozalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino [1,2-,a] quinoxalines
Welmaker, Gregory S.,Nelson, James A.,Sabalski, Joan E.,Sabb, Annmarie L.,Potoski, John R.,Graziano, Denise,Kagan, Michael,Coupet, Joseph,Dunlop, John,Mazandarani, Hossein,Rosenzweig-Lipson, Sharon,Sukoff, Stacey,Zhang, Yingxin
, p. 1991 - 1994 (2007/10/03)
A series of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro- 1H-pyrazino[1,2-a]-quinoxalines was shown to exhibit 5-HT(2C) agonist binding and functional activity. Compound 21R inhibited food intake over 2 h in fasted, male Sprague-Dawley rats with ED50 values of 2 mg/kg (ip) and 10 mg/kg (po). (C) 2000 Elsevier Science Ltd.
