278788-60-6

Basic information

• Product Name: (R)-4-Boc-Piperazine-3-carboxylic acid
• Synonyms: 1-BOC-PIPERAZINE-2-(R)-CARBOXYLIC ACID;(R)-PIPERAZINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER;(R)-1-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID;(R)-1-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID;(R)-1-Boc-piperazine-2-carboxylic acid;(R)-4-Boc-Piperazine-3-carboxylicacid;N-Boc-piperazine-2-carboxylic acid;1,2-Piperazinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2R)-
• CAS NO: 278788-60-6
• Molecular Formula: C₁₀H₁₈N₂O₄
• Molecular Weight: 230.26
• Product Categories: pharmacetical;Piperaizine;amino acids
• Mol File: 278788-60-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 243-247 ºC (DEC.)
• Boiling Point: 371.8 °C at 760 mmHg
• Flash Point: 178.6 °C
• Appearance: /
• Density: 1.193 g/cm³
• Vapor Pressure: 1.5E-06mmHg at 25°C
• Refractive Index: 1.495
• Storage Temp.: Refrigerated.
• PKA: 2.90±0.20(Predicted)
• CAS DataBase Reference: (R)-4-Boc-Piperazine-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-Boc-Piperazine-3-carboxylic acid(278788-60-6)
• EPA Substance Registry System: (R)-4-Boc-Piperazine-3-carboxylic acid(278788-60-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• Hazardous Substances Data: 278788-60-6(Hazardous Substances Data)

Usage

Description

(R)-4-Boc-Piperazine-3-carboxylic acid is a chiral organic compound that features a Boc-protected piperazine ring and a carboxylic acid group. It is a valuable intermediate in the synthesis of various pharmaceuticals and bioactive molecules due to its unique structural features and reactivity.

Uses

Used in Pharmaceutical Industry:
(R)-4-Boc-Piperazine-3-carboxylic acid is used as a key intermediate in the synthesis of pyridoisoquinolines, which are VAMT2 inhibitors. These inhibitors are crucial for the treatment of hyperkinetic disorders, a group of conditions characterized by abnormally high levels of movement or activity.
In the preparation of pyridoisoquinolines, (R)-4-Boc-Piperazine-3-carboxylic acid plays a significant role due to its ability to form stable intermediates and facilitate the formation of the desired biologically active compounds. This makes it an essential component in the development of novel therapeutic agents for the management of hyperkinetic disorders.

InChI:InChI=1/C10H18N2O4/c1-10(2,3)16-9(15)12-5-4-11-6-7(12)8(13)14/h7,11H,4-6H2,1-3H3,(H,13,14)/t7-/m1/s1

Upstream product

• 138775-02-7 (2R)-4-[(benzyloxy)carbonyl]-1-[(tert-butoxy)carbonyl]piperazine-2-carboxylic acid 

Downstream Products

• 894801-90-2 (2R)-1-tert-butoxycarbonyl-4-isopropyl-piperazine-2-carboxylic acid 
• 894801-94-6 tert-butyl (2R)-2-[(4-benzylpiperazin-1-yl)carbonyl]piperazine-1-carboxylate 
• 363192-62-5 (2R)-1-(tert-butoxycarbonyl)-4-methylpiperazine-2-carboxylic acid 
• 252990-05-9 1-(tert-butyl) 2-methyl (R)-piperazine-1,2-dicarboxylate 

Relevant articles and documents

FARNESYL PROTEIN TRANSFERASE INHIBITORS

Disclosed are compounds of formula (1.0), wherein R represents a cyclic moiety to which is bound an imodazolylalkyl group; R represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.