27884-09-9

Basic information

• Product Name: 2-(4-Methoxyphenyl)benzothiophene
• Synonyms: 2-(4-METHOXY PHENYL)BENZOTHIOPHENE;2-(4-methoxypheny)benzothiophene
• CAS NO: 27884-09-9
• Molecular Formula: C₁₅H₁₂OS
• Molecular Weight: 240.32
• Mol File: 27884-09-9.mol
• Article Data: 64

Chemical Properties

• Melting Point: 186-189°C
• Boiling Point: 401°C
• Flash Point: 196°C
• Appearance: /
• Density: 1.187
• CAS DataBase Reference: 2-(4-Methoxyphenyl)benzothiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Methoxyphenyl)benzothiophene(27884-09-9)
• EPA Substance Registry System: 2-(4-Methoxyphenyl)benzothiophene(27884-09-9)

Safety Data

• Hazardous Substances Data: 27884-09-9(Hazardous Substances Data)

Usage

General Description

2-(4-Methoxyphenyl)benzothiophene is a chemical compound with the molecular formula C16H12OS. It is classified as a benzothiophene derivative, which is a type of heterocyclic compound containing a benzene ring fused to a thiophene ring. The presence of a methoxy group on the phenyl ring makes it a substituted benzothiophene. This chemical is commonly used in organic synthesis and pharmaceutical research, where it may serve as a building block for the preparation of various biologically active compounds. Its properties and potential applications make it an important chemical in the field of medicinal and material chemistry.

Upstream product

• 21875-72-9 1-(4-methoxy-phenyl)-2-phenylsulfanyl-ethanone 
• 5394-13-8 2-bromo-1-benzothiophene 
• 7342-82-7 3-Bromothianaphthene 
• 84904-70-1 1-((4-methoxyphenyl)ethynyl)-2-(methylsulfanyl)benzene 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 95-15-8 Benzo[b]thiophene 
• 98437-23-1 benzo[b]thiophene-2-boronic acid 
• 696-62-8 para-iodoanisole 
• 765292-64-6 1-[2'-(tert-butylsulfanyl)phenyl]-1-[4''-methoxyphenyl]ethanone 
• 765292-75-9 2-[2'-(tert-butyldimethylsilylsulfanyl)phenyl]-1.3-dithiane 
• 765292-74-8 2-(2'-mercaptophenyl)-1,3-dithiane 
• 765292-68-0 2-[2'-(tert-butylsulfanyl)phenyl]-1,3-dithiane 
• 765292-73-7 C₂₀H₂₂S₆ 
• 53165-22-3 2-(2'-aminophenyl)-1,3-dithiane 

Downstream Products

• 81344-89-0 2-(4-methoxyphenyl)benzo[b]thiophene 1,1-dioxide 
• 140911-50-8 2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl 4-[2-(1-piperidyl)ethoxy]phenyl ketone 
• 193964-26-0 2-(4-methoxyphenyl)benzo[b]thiophen-3-yl 3-bromo-4-methoxyphenyl ketone 
• 193964-29-3 (2-(4-methoxyphenyl)benzo[b]thiophene-3-yl)-(6-chloropyrid-3-yl)ketone 
• 63675-96-7 2-(4-methoxy-phenyl)benzo[b]thiophen-3-yl 4-methoxyphenyl ketone 
• 262425-29-6 (2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)-(2-methoxyphenyl)ketone 
• 26563-22-4 3-bromo-2-(4-methoxyphenyl)benzo[b]thiophene 
• 193964-32-8 methyl 4-[[2-(4-methoxyphenyl)benzo[b]thiophen-3-yl]thio]phenyl ether 
• 193964-33-9 4-[[2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl]thio]phenol 
• 193964-38-4 methyl 4-[1-[2-(4-methoxyphenyl)benzo[b]thiophen-3-yl]ethenyl]phenyl ether 
• 262425-31-0 2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl 2-hydroxyphenyl ketone 
• 193964-39-5 4-[1-[2-(4-methoxyphenyl)benzo[b]thiophen-3-yl]ethenyl]phenol 
• 193964-30-6 2-(4-methoxyphenyl)benzo[b]thiophen-3-yl 6-[2-(1-pyrrolidinyl)ethoxy]pyrid-3-yl ketone 
• 193964-31-7 2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl 6-[2-(1-pyrrolidinyl)ethoxy]pyrid-3-yl ketone 

Relevant articles and documents

Synthesis of 2-Substituted Benzothio(seleno)phenes and Indoles via Ag-Catalyzed Cyclization/Demethylation of 2-Alkynylthio(seleno)anisoles and 2-Alkynyldimethylanilines

An Ag-catalyzed cyclization/demethylation of 2-alkynylthio(seleno)anisoles and 2-alkynyldimethylanilines is described and applied for the construction of valuable benzothio(seleno)phenes as well as indoles. Various 2-substituted benzothio(seleno)phenes and indoles were obtained in good to excellent yields under mild reaction conditions with low catalyst loading. An application of this new method is also exemplified with a concise synthesis of a bioactive molecule precursor. Furthermore, a conceivable reaction mechanism is proposed with supports from isotope-exchange experiments.

Infrared Irradiation-Assisted Solvent-Free Pd-Catalyzed (Hetero)aryl-aryl Coupling via C?H Bond Activation

The increasing attention towards environmentally friendly synthetic protocols has boosted studies directed to the development of green and sustainable methods for direct C?H bond arylation of (hetero)arenes. In this context, here the infrared (IR) irradia

Nickel-catalyzed and Li-mediated regiospecific C-H arylation of benzothiophenes

A nickel-based catalytic system for the regiospecific C2-H arylation of benzothiophene has been established. NiCl2(bpy) is used as a catalyst in combination with LiHMDS as a base in dioxane. The catalytic system is applicable to a variety of functionalized benzothiophenes, as well as other heteroarenes including thiophene, benzodithiophene, benzofuran and selenophene in combination with iodo aryl electrophiles. The role of LiHMDS as a uniquely potent base and a postulated mechanism are discussed. The applicability of this system is finally demonstrated for the synthesis of an intermediate of an active pharmaceutical ingredient.