279692-23-8 Usage
Description
Ethyl 4-(4,4-dimethyl-2,6-dioxopiperidin-1-yl)benzoate is a chemical compound with the molecular formula C18H23NO4. It is a derivative of benzoic acid and contains a piperidine ring, making it useful in the development of various pharmaceuticals and agrochemicals. Ethyl 4-(4,4-dimethyl-2,6-dioxopiperidin-1-yl)benzoate is a white to off-white solid with a molecular weight of 317.38 g/mol.
Uses
Used in Pharmaceutical Industry:
Ethyl 4-(4,4-dimethyl-2,6-dioxopiperidin-1-yl)benzoate is used as an intermediate or building block in the synthesis of pharmaceutical drugs and other organic compounds. Its unique structure allows it to be a key component in the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
Ethyl 4-(4,4-dimethyl-2,6-dioxopiperidin-1-yl)benzoate is also used in the synthesis of agrochemicals, such as pesticides and herbicides. Its versatility in chemical reactions makes it a valuable component in the development of effective and environmentally friendly agricultural products.
Used in Organic Synthesis:
Ethyl 4-(4,4-dimethyl-2,6-dioxopiperidin-1-yl)benzoate is used as a starting material in various organic synthesis processes. Its reactivity and functional groups make it suitable for the preparation of a wide range of organic compounds for research and industrial applications.
Used in Drug Development:
Ethyl 4-(4,4-dimethyl-2,6-dioxopiperidin-1-yl)benzoate is used in drug development for its potential applications in creating new pharmaceuticals. Its unique structure and properties make it a promising candidate for the development of innovative drugs with improved efficacy and safety profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 279692-23-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,9,6,9 and 2 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 279692-23:
(8*2)+(7*7)+(6*9)+(5*6)+(4*9)+(3*2)+(2*2)+(1*3)=198
198 % 10 = 8
So 279692-23-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H19NO4/c1-4-21-15(20)11-5-7-12(8-6-11)17-13(18)9-16(2,3)10-14(17)19/h5-8H,4,9-10H2,1-3H3
279692-23-8Relevant articles and documents
Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo
Wendt, Michael D.,Shen, Wang,Kunzer, Aaron,McClellan, William J.,Bruncko, Milan,Oost, Thorsten K.,Ding, Hong,Joseph, Mary K.,Zhang, Haichao,Nimmer, Paul M.,Ng, Shi-Chung,Shoemaker, Alexander R.,Petros, Andrew M.,Oleksijew, Anatol,Marsh, Kennan,Bauch, Joy,Oltersdorf, Tilman,Belli, Barbara A.,Martineau, Darlene,Fesik, Stephen W.,Rosenberg, Saul H.,Elmore, Steven W.
, p. 1165 - 1181 (2007/10/03)
Development of a rationally designed potentiator of cancer chemotherapy, via inhibition of Bcl-XL function, is described. Lead compounds generated by NMR screening and directed parallel synthesis displayed sub-μM binding but were strongly deactivated in the presence of serum. The dominant component of serum deactivation was identified as domain III of human serum albumin (HSA); NMR solution structures of inhibitors bound to both Bcl-X L and HSA domain III indicated two potential optimization sites for separation of affinities. Modifications at both sites resulted in compounds with improved Bcl-XL binding and greatly increased activity in the presence of human serum, culminating in 73R, which bound to Bcl-XL with a Ki of 0.8 μM. In a cellular assay 73R reversed the protection afforded by Bcl-XL overexpression against cytokine deprivation in FL5.12 cells with an EC50 of 0.47 μM. 73R showed little effect on the viability of the human non small cell lung cancer cell line A549. However, consistent with the proposed mechanism, 73R potentiated the activity of paclitaxel and UV irradiation in vitro and potentiated the antitumor efficacy of paclitaxel in a mouse xenograft model.
N-Acylsulfonamide apoptosis promoters
-
, (2008/06/13)
N-Benzoyl arylsulfonamides having the formula Are BCL-X1 inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-X1 inhibiting compositions and methods of promoting apoptosis in a mammal.