28006-42-0

Basic information

• Product Name: 2,6-DIPHENYL-3(2H)-PYRIDAZINONE
• Synonyms: 2,6-DIPHENYL-3(2H)-PYRIDAZINONE
• CAS NO: 28006-42-0
• Molecular Formula: C₁₆H₁₂N₂O
• Molecular Weight: 248.28
• Mol File: 28006-42-0.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,6-DIPHENYL-3(2H)-PYRIDAZINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIPHENYL-3(2H)-PYRIDAZINONE(28006-42-0)
• EPA Substance Registry System: 2,6-DIPHENYL-3(2H)-PYRIDAZINONE(28006-42-0)

Safety Data

• Hazardous Substances Data: 28006-42-0(Hazardous Substances Data)

Usage

Appearance

yellow crystalline solid

Uses

photographic developer, antioxidant

Properties

produces high-quality photographic images, acts as an antioxidant

Medical applications

potential cancer cell growth inhibition, anti-inflammatory properties

Upstream product

• 6627-28-7 4-phenyl-4-phenylhydrazono-trans-crotonic acid 
• 108-24-7 acetic anhydride 
• 4578-59-0 2,6-diphenyl-4,5-dihydro-3(2H)-pyridazinone 
• 100-63-0 phenylhydrazine 
• 2051-95-8 succinylbenzene 
• 17812-07-6 Benzoylacrylic acid 
• 108-86-1 bromobenzene 
• 66549-13-1 6-(2-chlorophenyl)-4,5-dihydropyridazin-3(2H)-one 
• 139050-32-1 6-(2-bromophenyl)-4,5-dihydropyridazin-3(2H)-one 
• 1011-46-7 6-phenyl-2,3,4,5-tetrahydropyridazin-3-one 
• 2166-31-6 6-phenylpyridazin-3(2H)-one 

Downstream Products

• 37906-50-6 2-(4-bromophenyl)-6-phenylpyridazin-3(2H)-one 
• 75616-24-9 2,4,6-triphenyl-4,5-dihydro-2H-pyridazin-3-one 
• 87780-12-9 2,6-diphenyl-2H-pyridazine-3-thione 
• 87780-04-9 1-(4-Bromo-phenyl)-2-[2,6-diphenyl-2H-pyridazin-(3E)-ylidene]-ethanone 

Relevant articles and documents

Copper-catalyzed aerobic dehydrogenation of C-C to C=C bonds in the synthesis of pyridazinones

A simple and efficient procedure for the synthesis of pyridazin-3(2H)-ones through copper-catalyzed dehydrogenation of a single C-C bond of 4,5-dihydropyridazin-3(2H)-ones to a C=C bond with oxygen as the terminal oxidant is described. Functional groups including hydroxy, carboxylic, bromo, chloro, cyano, nitro and alkoxy were all tolerated under the reaction conditions. Moreover, this methodology was applied to the preparation of a series of structurally similar N-substituted 6-phenylpyridazinone compounds containing fluorine. The dehydrogenation reactions exhibit good yields and selectivity. Copper-catalyzed dehydrogenation of a C-C bond of 4,5-dihydropyridazinones to a C=C bond with oxygen as the terminal oxidant is described. Various functional groups were tolerated under the reaction conditions. The method was also applied to the preparation of a series of N-substituted 6-phenylpyridazinones containing fluoride. The dehydrogenation reactions exhibit good yields and selectivity.

Relay catalysis by a multifunctional Cu catalyst in a tandem dehydro-/dehalogenation sequence along with N-arylation

A Cu-catalyzed tandem dehydrogenation/dehalogenation sequential reaction along with N-arylation has been developed for the synthesis of pyridazinone derivatives in an aerobic and aqueous environment. To achieve the transformation of three chemical bonds in a one-pot reaction, a multifunctional copper catalyst was used which afforded excellent activity, high selectivity, and recyclability. The catalytic system consists of a water-soluble Cusalen complex and Na2CO3 in neat water and an air atmosphere.

Microwave assisted synthesis of 4,6-diarylpyridazin-3(2H)-ones in solid state

Microwave assisted synthesis of dihydropyridazin-3(2H)-ones and the subsequent dehydrogenation using selenium dioxide are described.