28049-60-7

Basic information

• Product Name: 1-(3-Chlorophenyl)cyclobutanecarbonitrile
• Synonyms: 1-(3-Chlorophenyl)cyclobutanecarbonitrile;1-(3-chlorophenyl)cyclobutane-1-carbonitrile
• CAS NO: 28049-60-7
• Molecular Formula: C₁₁H₁₀ClN
• Molecular Weight: 191.6568
• Mol File: 28049-60-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(3-Chlorophenyl)cyclobutanecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-Chlorophenyl)cyclobutanecarbonitrile(28049-60-7)
• EPA Substance Registry System: 1-(3-Chlorophenyl)cyclobutanecarbonitrile(28049-60-7)

Safety Data

• Hazardous Substances Data: 28049-60-7(Hazardous Substances Data)

Usage

Appearance

White to light brown powder

Solubility

Slightly soluble in water, soluble in organic solvents

Uses

a. Intermediate for the synthesis of pharmaceuticals and agrochemicals
b. Building block in organic synthesis for creating functional groups (amides, esters, amines)
c. Studied for potential in medicinal chemistry due to unique structure and pharmacological activities

Safety

Handle with care and follow proper safety protocols due to potential hazardous properties

Upstream product

• 1529-41-5 3-chloro-benzeneacetonitrile 
• 109-64-8 1,3-dibromo-propane 

Downstream Products

• 29786-46-7 1-(3-chlorophenyl)cyclobutane-1-carboxamide 
• 29786-56-9 <1-(m-Chlorophenyl)-cyclobutyl>-carbonylisocyanat 
• 29770-32-9 (<1-(m-Chlorophenyl)-cyclobutyl>-carbonyl)-harnstoff 
• 29771-04-8 (<1-(m-Chlorophenyl)cyclobutyl>carbonyl)carbamsaeuremethylester 
• 29786-29-6 (<1-(m-Chlorophenyl)cyclobutyl>carbonyl)carbamsaeureethylester 
• 161190-32-5 1-[1-(3-chlorophenyl)cyclobutyl]ethanone 
• 151157-55-0 C₁₁H₁₁ClO₂ 

Relevant articles and documents

Synthesis method of arylcyclobutane compound

The present invention discloses a method for synthesizing an arylcyclobutane compound to 1eq phenylacetonitrile and 1.1eq 1-bromo-3-chloropropane as raw material, N,N- dimethylacetamide as a solvent, plus 2.5eq sodium hydride, under the protection of iner

Oxadiazole Amine Derivative Compounds as Histone Deacetylase 6 Inhibitor, and the Pharmaceutical Composition Comprising the same

The present invention relates to a novel compound having an activity of inhibiting histone deacetylase 6 (HDAC6), an optical isomer thereof or a pharmaceutically acceptable salt thereof, a use thereof for preparation of a drug for treatment, a pharmaceutical composition comprising the same, a treatment method using the composition, and a method for preparing the same. The novel compound, an optical isomer thereof or a pharmaceutically acceptable salt thereof according to the present invention has an activity of inhibiting histone deacetylase 6 (HDAC6), and is effective for preventing or treating HDAC6-related diseases, including infectious diseases; neoplasm; endocrine, nutritional and metabolic diseases; mental and behavior disorders; nerve disorders; eye and adnexa diseases; cardiovascular diseases; respiratory diseases; digestive organ diseases; skin and subcutaneous tissue diseases; musculoskeletal and connective tissue diseases; or congenital malformation, deformation and chromosomal abnormality.COPYRIGHT KIPO 2017

Method of treating addiction or dependence using a ligand for a monoamine receptor or transporter

One aspect of the present invention relates to a method of treating of drug addiction or drug dependence in a mammal, comprising the step of administering to a mammal in need thereof a therapuetically effective amount of a heterocyclic compound, e.g., a 3-substituted piperidine. In a preferred embodiment, the method of the present invention treats cocaine addiction or methamphetamine addiction.