2816-12-8

Basic information

• Product Name: 4-isopropyloxazolidine-2,5-dione
• Synonyms: 4-isopropyloxazolidine-2,5-dione;Einecs 220-566-4
• CAS NO: 2816-12-8
• Molecular Formula: C₆H₉NO₃
• Molecular Weight: 143.14056
• EINECS: 220-566-4
• Mol File: 2816-12-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.183g/cm³
• Refractive Index: 1.456
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-isopropyloxazolidine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-isopropyloxazolidine-2,5-dione(2816-12-8)
• EPA Substance Registry System: 4-isopropyloxazolidine-2,5-dione(2816-12-8)

Safety Data

• Hazardous Substances Data: 2816-12-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 57, p. 2755, 1992 DOI: 10.1021/jo00035a044

InChI:InChI=1/C6H9NO3/c1-3(2)4-5(8)10-6(9)7-4/h3-4H,1-2H3,(H,7,9)

Upstream product

• 75-44-5 phosgene 
• 516-06-3 D,L-valine 
• 111398-44-8 (2R)-2-(methoxycarbonyl amino)-3-methylbutanoic acid 
• 111421-95-5 N-ethoxycarbonyl-DL-valine 
• 1149-26-4 N-benzyloxycarbonylvaline 
• 15984-93-7 valine, N-trimethylsilyl-, trimethylsilyl ester 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 26081-00-5 N-carbamoyl-valine 

Downstream Products

• 55721-76-1 valine phenethylamide 
• 13474-14-1 valinamide 
• 40331-73-5 4-isopropyl-3-(2-nitro-phenylsulfanyl)-oxazolidine-2,5-dione 
• 80875-24-7 DL-Val-NHi-Pr 
• 686-43-1 valylglycine 
• 462-60-2 N-carbamoylglycine 
• 72-18-4 L-valine 
• 3918-94-3 Val-Val 
• 394210-42-5 4-isopropyl-2,5-dioxo-oxazolidine-3-carboxylic acid benzyl ester 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 24210-19-3 methyl (2S)-3-methyl-[(benzyloxy)carbonylamino]butanoate 
• 154674-67-6 methyl (R)-(N-benzyloxycarbonyl)valinate 
• 40331-81-5 o-Nitrophenylsulfenyl-D,L-Valinamid 
• 14297-28-0 N-DL-valyl-glycine 

Relevant articles and documents

ANTIMICROBIAL COMPOSITION COMBINATIONS COMPRISING STAR SHAPED PEPTIDE POLYMERS

This invention relates to compositions including antibacterial compounds. The invention also relates to the use of the compositions in methods of treating bacterial infections. In one aspect the present invention also provides a method of increasing the susceptibility of bacteria to the anti-bacterial activity of a compound, the method comprising contacting the bacteria with a star shaped peptide polymer of the invention, thereby increasing the susceptibility of the bacteria to the anti-bacterial activity of the compound. Preferably, the method further includes the step of contacting the bacteria with the compound for which the bacteria have increased susceptibility to. The invention is further relates to the combination of a star shaped peptide polymer and an anti- bacterial compound that restore the sensitivity of antibiotic resistant bacteria to antibiotics that are otherwise ineffective when administered alone.

A new simple and quantitative synthesis of α-aminoacid-N-carboxyanhydrides (oxazolidines-2,5-dione)

Nitrosation of chiral N-carbamoylaminoacids with a mixture of NO and O2 gives, with the same configuration and in quantitative yield the corresponding α-aminoacid-N-carboxyanhydrides (NCA), well known precursors of peptides. The by products of this reaction are N2 and H2O. Copyright (C) 1996 Elsevier Science Ltd.

ENANTIOMERIC QUANTIFICATIONS OF AMINO ACIDS THROUGH THEIR Nα-ACYL AMIDES BY GAS CHROMATOGRAPHY.

Apparent separation of 1.1 or higher on Chiralsil Val III can be obtained for Nα-acyl N-alkyl aminoacid amides allowing the use of short capillary gas chromatographic columns.A clean derivatization protocol without racemization is described, proceding through the NCA derivatives that are prepared from "in situ" silylated amino acids with trimethylsilyl cyanide.