282537-68-2

Basic information

• Product Name: 2H-1,4-Oxazin-2-one, 5-chloro-3,6-diphenyl-
• CAS NO: 282537-68-2
• Molecular Formula: C16H10ClNO2
• Molecular Weight: 283.714
• Mol File: 282537-68-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2H-1,4-Oxazin-2-one, 5-chloro-3,6-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1,4-Oxazin-2-one, 5-chloro-3,6-diphenyl-(282537-68-2)
• EPA Substance Registry System: 2H-1,4-Oxazin-2-one, 5-chloro-3,6-diphenyl-(282537-68-2)

Safety Data

• Hazardous Substances Data: 282537-68-2(Hazardous Substances Data)

Upstream product

• 532-28-5 (RS)-mandelonitrile 
• 934-56-5 trimethyl(phenyl)stannane 
• 125850-00-2 3,5-dichloro-6-phenyl-2(H)-1,4-oxazin-2-one 
• 71-43-2 benzene 
• 595-90-4 tetraphenyltin(IV) 

Downstream Products

• 282537-82-0 1,4-diphenyl-2-oxa-5-azabicyclo[2.2.2]octan-3-one 
• 282537-72-8 6-chloro-1,4-diphenyl-2-oxa-5-azabicyclo[2.2.2]oct-5-en-3-one 

Relevant articles and documents

Investigation of the Diels-Alder cycloadditions of 2(H)-1,4-oxazin-2-ones

A variety of 5-chloro-2(H)-1,4-oxazin-2-ones bearing a range of substituents at their 3- and 6-positions undergo Diels-Alder cycloaddition as a 2-azadiene component with electron-rich, electron-deficient, and electron-neutral dienophiles. These reactions

Stereoselective conversion of 2H-1,4-oxazin-2-ones into 2,5,5-substituted piperidine-2-carboxamides and 2-methanamines and related octahydro-2H-pyrido[1,2-a]pyrazines, potential substance P antagonists

4-(Hetero)aryl-2-oxa-5-azabicyclo[2.2.2]octan-3-ones and 3,6-diones, formed via cycloaddition of 2H-1,4-oxazin-2-ones and ethene followed by functional group transformation, undergo lactone cleavage by reaction with amines to yield substituted 2-(hetero)aryl-5-hydroxy-2-piperidinecarboxamides. Subsequent reduction affords the corresponding 2-piperidinemethanamines. Both amide and amine compounds are of interest as potential Substance P antagonists. A detailed NMR study, supported by conformational calculations, of an octahydro-2H-pyrido[1,2-a]pyrazine analogue revealed the existence of a temperature and solvent dependent equilibrium mixture of transoid and cisoid invertomers.