28266-96-8

Basic information

• Product Name: 2-(4-NITRO-PHENYL)-IMIDAZO[1,2-A]PYRIMIDINE
• Synonyms: 2-(4-NITRO-PHENYL)-IMIDAZO[1,2-A]PYRIMIDINE;2-(4-Nitro-phenyl)-imidazo[1,2-a] pyrimidine, >92%
• CAS NO: 28266-96-8
• Molecular Formula: C₁₂H₈N₄O₂
• Molecular Weight: 240.22
• Mol File: 28266-96-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.44 g/cm³
• CAS DataBase Reference: 2-(4-NITRO-PHENYL)-IMIDAZO[1,2-A]PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-NITRO-PHENYL)-IMIDAZO[1,2-A]PYRIMIDINE(28266-96-8)
• EPA Substance Registry System: 2-(4-NITRO-PHENYL)-IMIDAZO[1,2-A]PYRIMIDINE(28266-96-8)

Safety Data

• Hazardous Substances Data: 28266-96-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 25, p. 129, 1988 DOI: 10.1002/jhet.5570250119

Upstream product

• 109-12-6 2-aminopyrimidine 
• 100-19-6 (4-nitrophenyl)ethanone 
• 56177-37-8 1-(4-nitrophenyl)-2-(p-tolylsulfonyloxy)ethanone 

Downstream Products

• 58609-93-1 4-{imidazo[1,2-a]pyrimidin-2-yl}aniline 
• 93745-55-2 2-(4-Nitro-phenyl)-3-nitroso-imidazo[1,2-a]pyrimidine 
• 103779-36-8 acetic acid-(4-imidazo[1,2-a]pyrimidin-2-yl-anilide) 
• 60472-21-1 [4-(4-nitrophenyl)-1H-imidazol-2-yl]amine 
• 60472-21-1 5-(4-nitrophenyl)-1H-imidazol-2-amine 

Relevant articles and documents

Studies in the imidazole series. 100. Synthesis of derivatives of imidazo[1,2-a]pyrimidine from 2-aminopyrimidines, methyl aryl ketones, and halogens

We have synthesized imidazo[1,2-a]pyrimidine derivatives by reaction of 2-aminopyrimidines with methyl aryl ketones and halogens (bromine, iodine). Using bromine leads to formation of 6-bromo- and 3,6-dibromo-substituted 2-arylimidazo[1,2-a]pyrimidines.

Synthesis and antibacterial activity of some imidazo[1,2-a[pyrimidine derivatives

A series of 75 imidazo[1,2-a]pyrimidine derivatives were synthesized. The 'in vitro' antibacterial activity of these compounds and their corresponding α-bromoketones against a variety of gram (+), gram (-) bacteria and Mycobacterium species is reported. Some of the prepared derivatives exhibited potent antimicrobial activity.