2834-79-9

Basic information

• Product Name: 2-amino-4-(4-biphenylyl)-thiazol
• Synonyms: 2-amino-4-(4-biphenylyl)-thiazol;usafek-4373
• CAS NO: 2834-79-9
• Molecular Formula: C₁₅H₁₂N₂S
• Molecular Weight: 252.33418
• Mol File: 2834-79-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 489 °C at 760 mmHg
• Flash Point: 249.5 °C
• Appearance: /
• Density: 1.23 g/cm³
• Vapor Pressure: 1.04E-09mmHg at 25°C
• Refractive Index: 1.665
• CAS DataBase Reference: 2-amino-4-(4-biphenylyl)-thiazol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-4-(4-biphenylyl)-thiazol(2834-79-9)
• EPA Substance Registry System: 2-amino-4-(4-biphenylyl)-thiazol(2834-79-9)

Safety Data

• Hazardous Substances Data: 2834-79-9(Hazardous Substances Data)

Usage

General Description

2-amino-4-(4-biphenylyl)-thiazol is a chemical compound with a thiazole ring substituted with an amino group and a biphenyl group. It is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. 2-amino-4-(4-biphenylyl)-thiazol has potential therapeutic properties and is being studied for its anti-inflammatory and anti-cancer activities. Additionally, it is being investigated for its use as a fluorescent marker in biological imaging. Due to its unique structure and properties, 2-amino-4-(4-biphenylyl)-thiazol has potential applications in the fields of medicine, chemistry, and biology.

InChI:InChI=1/C15H12N2S/c16-15-17-14(10-18-15)13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-10H,(H2,16,17)

Upstream product

• 92-91-1 biphenyl-4-acetaldehyde 
• 17356-08-0 thiourea 
• 135-73-9 2-Bromo-4'-phenylacetophenone 
• 2103-94-8 4-(4-bromophenyl)-1,3-thiazol-2-amine 
• 98-80-6 phenylboronic acid 
• 99-73-0 para-bromophenacyl bromide 
• 5707-44-8 4-ethylbiphenyl 

Downstream Products

• 71119-15-8 sulfanilic acid-(4-biphenyl-4-yl-thiazol-2-ylamide) 
• 40519-88-8 3-biphenyl-4-yl-5-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester 
• 28142-90-7 4-biphenyl-4-yl-2-(2,5-dimethyl-pyrrol-1-yl)-thiazole 
• 73644-75-4 3-biphenyl-4-yl-7-chloro-thiazolo[3,2-a]pyrimidin-5-one 
• 40519-72-0 [(4-biphenyl-4-yl-thiazol-2-ylamino)-methylene]-malonic acid diethyl ester 
• 77203-62-4 2-{[(E)-4-Biphenyl-4-yl-thiazol-2-ylimino]-methyl}-4,6-dibromo-phenol 
• 77203-48-6 2-{[(E)-4-Biphenyl-4-yl-thiazol-2-ylimino]-methyl}-phenol 
• 77203-55-5 2-{[(E)-4-Biphenyl-4-yl-thiazol-2-ylimino]-methyl}-4-bromo-phenol 

Relevant articles and documents

Synthesis, X-ray crystallographic, spectroscopic and computational studies of aminothiazole derivatives

Aminothiazole organic compounds have diverse biological applications. Herein we report the synthesis of two aminothiazole derivatives: 4-(biphenyl-4-yl)thiazol-2-amine (1) and 4-(2′,4′-difluorobiphenyl-4-yl)thiazol-2-amine (2) via Suzuki-Miyaura cross cou

SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES

The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.

Carbon tetrabromide mediated oxidative cyclocondensation of ketones and thioureas: An easy access to 2-aminothiazoles

A simple, mild, and efficient one-pot method for the synthesis of substituted 2-aminothiazoles has been reported. The reaction involves the formation of sulfenyl bromide as an umpolung intermediate of nucleophilic sulfur, which is responsible for C-S bond formation leading to oxidative cyclization of ketones and thioureas to furnish the desired products. Carbon tetrabromide was used as a convenient and mild brominating reagent under basic condition at room temperature to give 2-aminothiazoles in good to excellent yields.